Tbio IRF3 Interferon regulatory factor 3

Protein Summary

Description

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• Q14653
• A8K7L2
• B2RAZ3
• Q5FBY1
• Q5FBY2
• Q5FBY4
• Q7Z5G6
• IRF-3

Gene Name

• IRF3

Ensembl ID

• ENST00000309877
• ENSP00000310127
• ENSG00000126456
• ENST00000377139
• ENSP00000366344
• ENST00000442265
• ENSP00000400378
• ENST00000596765
• ENSP00000470512
• ENST00000597198
• ENSP00000469113
• ENST00000599223
• ENSP00000471358
• ENST00000600022
• ENSP00000472700
• ENST00000601291
• ENSP00000471896

Symbol

• IIAE7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
biological term	0.96
hub protein	0.96
kinase	0.87
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Interferon Regulatory Factor 3

Protein / Nucleic Acid Binding / Interferon Regulatory Factor 3

Protein / ... / Winged Helix/forkhead Transcription Factor / Interferon Regulatory Factor 3

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Interferon Regulatory Factor 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1214.58   (req: < 5)

Gene RIFs: 306   (req: <= 3)

Antibodies: 1189   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1214.58   (req: >= 5)

Gene RIFs: 306   (req: > 3)

Antibodies: 1189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0