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Tbio
IRF3
Interferon regulatory factor 3

Protein Summary
Description
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309877
  • ENSP00000310127
  • ENSG00000126456
  • ENST00000377139
  • ENSP00000366344
  • ENST00000442265
  • ENSP00000400378
  • ENST00000596765
  • ENSP00000470512
  • ENST00000597198
  • ENSP00000469113
  • ENST00000599223
  • ENSP00000471358
  • ENST00000600022
  • ENSP00000472700
  • ENST00000601291
  • ENSP00000471896

Symbol
  • IIAE7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
biological term
0.96
hub protein
0.96
kinase
0.87
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1000.28   (req: < 5)
Gene RIFs: 240   (req: <= 3)
Antibodies: 1189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1000.28   (req: >= 5)
Gene RIFs: 240   (req: > 3)
Antibodies: 1189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
1
1
0
1.1
42.8
1
1
0
1.2
37.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
0
1.1
42.8
0
1.2
37.1
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (109)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (R-HSA-936964)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Name
Explore in Pharos
Explore in Source
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
Cytosolic sensors of pathogen-associated DNA
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Gene Ontology Terms (38)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred by Curator (IC)
NTNU_SB
Protein-Protein Interactions (408)
1 – 10 of 408
MSRA
Tbio
Family: Enzyme
Novelty: 0.00595154
p_int: 0.997287135
p_ni: 0.000242387
p_wrong: 0.002470477
Score: 0.309
Data Source: BioPlex,STRINGDB
GLMN
Tbio
Novelty: 0.01940401
p_int: 0.996775288
p_ni: 0.003224712
Score: 0.159
Data Source: BioPlex,STRINGDB
MOCOS
Tbio
Family: Enzyme
Novelty: 0.05022905
p_int: 0.990436916
p_ni: 0.009563083
Score: 0.173
Data Source: BioPlex,STRINGDB
USP19
Tbio
Family: Enzyme
Novelty: 0.04078253
p_int: 0.979937292
p_ni: 0.020062708
Score: 0.213
Data Source: BioPlex,STRINGDB
DOCK7
Tbio
Novelty: 0.03425586
p_int: 0.897490163
p_ni: 0.102509837
Score: 0.158
Data Source: BioPlex,STRINGDB
C5orf34
Tdark
Novelty: 1.01063928
p_int: 0.875916862
p_ni: 0.119412084
p_wrong: 0.004671054
Data Source: BioPlex
CCDC88A
Tbio
Novelty: 0.01077253
p_int: 0.795612992
p_ni: 0.204386999
p_wrong: 9e-9
Score: 0.175
Data Source: BioPlex,STRINGDB
ANKRD40
Tdark
Novelty: 1.06633958
p_int: 0.754155657
p_ni: 0.245844343
Score: 0.177
Data Source: BioPlex,STRINGDB
TBK1
Tchem
Family: Kinase
Novelty: 0.00194753
Score: 0.998
Data Source: Reactome,STRINGDB
DDX58
Tbio
Family: Enzyme
Novelty: 0.00080099
Score: 0.996
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1000.28

PubMed score by year
PubTator Score  719.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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