RASA3
Ras GTPase-activating protein 3
Protein Summary
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
- ENST00000334062
- ENSP00000335029
- ENSG00000185989
- ENST00000630618
- ENSP00000486064
- ENSG00000280477
- GAPIII
- GAP1IP4BP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.94 | ||
protein domain | 0.92 | ||
transcription factor perturbation | 0.88 | ||
disease perturbation | 0.87 | ||
cell type or tissue | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.52 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 263 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.52 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 263 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (66)
Nearest Tclin Targets (3)
Downstream (3)
1 – 3 of 3
Pathways (272)
Reactome (14)
KEGG (1)
PathwayCommons (1)
WikiPathways (256)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | FLT3 Signaling | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Disease | ||||
Diseases of signal transduction | ||||
FLT3 Signaling | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (3)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (26)
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 6 | 7 | 98.5 | ||||||
lymphocyte count | 3 | 6 | 7 | 98.5 | ||||||
lymphocyte percentage of leukocytes | 1 | 3 | 3 | 90.9 | ||||||
lymphocyte percentage of leukocytes | 1 | 3 | 3 | 90.9 | ||||||
triglyceride measurement | 2 | 2 | 2 | 82.4 | ||||||
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lymphocyte count | 7 | 98.5 | |||||
lymphocyte count | 7 | 98.5 | |||||
lymphocyte percentage of leukocytes | 3 | 90.9 | |||||
lymphocyte percentage of leukocytes | 3 | 90.9 | |||||
triglyceride measurement | 2 | 82.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | RAS p21 protein activator 3 | VGNC:14788 | 452684 | |||||
Macaque | RAS p21 protein activator 3 | 698964 | ||||||
Mouse | MGI:1197013 | 19414 | ||||||
Rat | RGD:69365 | 29372 | ||||||
Dog | RAS p21 protein activator 3 | VGNC:45361 | 476998 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | RAS p21 protein activator 3 | |||||
Macaque | RAS p21 protein activator 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | RAS p21 protein activator 3 | |||||
Publication Statistics
PubMed Score 38.52
PubMed score by year
PubTator Score 23.48
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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