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Tbio
IL13RA2
Interleukin-13 receptor subunit alpha-2

Protein Summary
Description
Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243213
  • ENSP00000243213
  • ENSG00000123496
  • ENST00000371936
  • ENSP00000361004

Symbol
  • IL13R
  • CT19
  • IL-13R
  • IL13BP
  • CD213A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
tissue
0.71
tissue sample
0.66
biological term
0.65
protein domain
0.58


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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.28   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 507   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.28   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 507   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
interleukin 13 receptor subunit alpha 2
708339
Mouse
MGI:1277954
16165
Rat
RGD:620838
171060
Dog
interleukin 13 receptor subunit alpha 2
VGNC:41938
403622
Cow
interleukin 13 receptor subunit alpha 2
VGNC:30115
616008
Species
Name
OMA
EggNOG
Inparanoid
Macaque
interleukin 13 receptor subunit alpha 2
Mouse
Rat
Dog
interleukin 13 receptor subunit alpha 2
Cow
interleukin 13 receptor subunit alpha 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14627-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-4 and Interleukin-13 signaling
Signaling by Interleukins
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (176)
1 – 10 of 176
TSHZ3
Tbio
Family: TF
Novelty: 0.02963612
p_int: 0.999999796
p_ni: 2.02e-7
p_wrong: 2e-9
Data Source: BioPlex
ENDOD1
Tdark
Family: Enzyme
Novelty: 0.26430864
p_int: 0.999982674
p_ni: 0.000017321
p_wrong: 5e-9
Data Source: BioPlex
NEK6
Tchem
Family: Kinase
Novelty: 0.02394134
p_int: 0.999887756
p_ni: 0.000111591
p_wrong: 6.52e-7
Data Source: BioPlex
C17orf80
Tbio
Novelty: 0.15267004
p_int: 0.999808813
p_ni: 0.000191187
Data Source: BioPlex
SLC25A23
Tbio
Family: Transporter
Novelty: 0.10446757
p_int: 0.999063132
p_ni: 0.000936843
p_wrong: 2.5e-8
Data Source: BioPlex
RNASEL
Tchem
Family: Kinase
Novelty: 0.00165549
p_int: 0.998217819
p_ni: 0.001781793
p_wrong: 3.88e-7
Score: 0.161
Data Source: BioPlex,STRINGDB
MAP2K7
Tchem
Family: Kinase
Novelty: 0.00916401
p_int: 0.99802078
p_ni: 0.00197922
Data Source: BioPlex
STOML1
Tbio
Novelty: 0.05746576
p_int: 0.997483433
p_ni: 0.000077257
p_wrong: 0.00243931
Score: 0.189
Data Source: BioPlex,STRINGDB
ZNF195
Tdark
Family: TF
Novelty: 0.23029736
p_int: 0.996537693
p_ni: 0.00321101
p_wrong: 0.000251298
Data Source: BioPlex
ST3GAL2
Tbio
Family: Enzyme
Novelty: 0.03503891
p_int: 0.995895859
p_ni: 0.004104119
p_wrong: 2.3e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  28.28

PubMed score by year
PubTator Score  144.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer