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Tbio
ITIH4
Inter-alpha-trypsin inhibitor heavy chain H4

Protein Summary
Description
Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266041
  • ENSP00000266041
  • ENSG00000055955
  • ENST00000406595
  • ENSP00000384425

Symbol
  • IHRP
  • ITIHL1
  • PK120
  • H4P
  • IHRP
  • GP120
  • PK120
  • ITIHL1
  • PK-120
  • ITI-HC4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
virus perturbation
1
disease perturbation
0.83
gene perturbation
0.66
tissue sample
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3333.04   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 395   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3333.04   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 395   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
1
1
1
74.7
depressive symptom measurement
1
1
1
74.7
self reported educational attainment
1
1
1
65.2
body mass index
1
1
1
54.1
heel bone mineral density
1
1
1
46.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
1
74.7
depressive symptom measurement
1
74.7
self reported educational attainment
1
65.2
body mass index
1
54.1
heel bone mineral density
1
46.4
Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Protein-Protein Interactions (156)
1 – 10 of 156
CCR5
Tclin
Family: GPCR
Novelty: 0.00022549
Score: 0.959
Data Source: STRINGDB
ERVW-1
Tbio
Novelty: 0.00038992
Score: 0.953
Data Source: STRINGDB
APOH
Tbio
Novelty: 0.00049117
Score: 0.949
Data Source: STRINGDB
CD4
Tclin
Novelty: 0.00001217
Score: 0.937
Data Source: STRINGDB
SERPINA4
Tbio
Novelty: 0.00483207
Score: 0.935
Data Source: STRINGDB
LGALS3BP
Tbio
Novelty: 0.0025302
Score: 0.93
Data Source: STRINGDB
ITIH3
Tbio
Novelty: 0.04201144
Score: 0.92
Data Source: STRINGDB
SELENOP
Tbio
Novelty: 0.00194637
Score: 0.917
Data Source: STRINGDB
SPP2
Tbio
Novelty: 0.04515855
Score: 0.917
Data Source: STRINGDB
ENPEP
Tchem
Family: Enzyme
Novelty: 0.00112857
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score  3333.04

PubMed score by year
PubTator Score  2512.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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