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Tbio
IHH
Indian hedgehog protein

Protein Summary
Description
Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity). This gene encodes a member of the hedgehog family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including an N-terminal fragment that is involved in signaling. Hedgehog family proteins are essential secreted signaling molecules that regulate a variety of developmental processes including growth, patterning and morphogenesis. The protein encoded by this gene specifically plays a role in bone growth and differentiation. Mutations in this gene are the cause of brachydactyly type A1, which is characteriz ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295731
  • ENSP00000295731
  • ENSG00000163501

Symbol
  • BDA1
  • HHG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
0.97
disease
0.77
phenotype
0.72
biological term
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 569.37   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 477   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 569.37   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 477   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
2
2
51.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
51.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
indian hedgehog
VGNC:10848
470652
Macaque
indian hedgehog
704046
Mouse
MGI:96533
16147
Rat
RGD:620021
84399
Horse
indian hedgehog [Source:HGNC Symbol;Acc:HGNC:5956]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
indian hedgehog
Macaque
indian hedgehog
Mouse
Rat
Horse
indian hedgehog [Source:HGNC Symbol;Acc:HGNC:5956]
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (96)
Activation of SMO (R-HSA-5635838)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of SMO
Reactome
Class B/2 (Secretin family receptors)
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Activation of SMO
Class B/2 (Secretin family receptors)
Disease
Diseases of signal transduction
GPCR ligand binding
Gene Ontology Terms (54)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (224)
1 – 10 of 224
PTCH1
Tbio
Novelty: 0.00077635
Score: 0.997
Data Source: STRINGDB
PTCH2
Tbio
Novelty: 0.00927849
Score: 0.99
Data Source: STRINGDB
SMO
Tclin
Family: GPCR
Novelty: 0.03235855
Score: 0.981
Data Source: STRINGDB
HHIP
Tbio
Novelty: 0.00982404
Score: 0.98
Data Source: STRINGDB
HHAT
Tbio
Family: Enzyme
Novelty: 0.003077
Score: 0.969
Data Source: STRINGDB
BOC
Tbio
Novelty: 0.10938194
Score: 0.963
Data Source: STRINGDB
CDON
Tbio
Novelty: 0.00447262
Score: 0.962
Data Source: STRINGDB
DISP2
Tbio
Novelty: 0.09502772
Score: 0.957
Data Source: STRINGDB
GAS1
Tbio
Novelty: 0.00423304
Score: 0.95
Data Source: STRINGDB
PTHLH
Tbio
Novelty: 0.00050137
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  569.37

PubMed score by year
PubTator Score  46.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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