NBR1
Next to BRCA1 gene 1 protein
Protein Summary
Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
- ENST00000341165
- ENSP00000343479
- ENSG00000188554
- ENST00000589872
- ENSP00000467816
- ENST00000590996
- ENSP00000466667
- 1A13B
- KIAA0049
- M17S2
- IAI3B
- M17S2
- MIG19
- 1A1-3B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.97 | ||
kinase perturbation | 0.93 | ||
transcription factor | 0.93 | ||
gene perturbation | 0.85 | ||
interacting protein | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 124.09 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 252 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 124.09 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 252 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0