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Tdark
ZNF460
Zinc finger protein 460

Protein Summary
Description
May be involved in transcriptional regulation. Zinc finger proteins, such as ZNF272, interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, May 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360338
  • ENSP00000353491
  • ENSG00000197714
  • ENST00000537645
  • ENSP00000446167

Symbol
  • ZNF272
  • HZF8
  • ZNF272
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.64
transcription factor binding site profile
0.61
cell type or tissue
0.58
protein domain
0.58
microRNA
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.8   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.8   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
75.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
75.9
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 460
VGNC:2165
100615257
Macaque
zinc finger protein 460
710080
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 460
Macaque
zinc finger protein 460
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14592-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Protein-Protein Interactions (31)
1 – 10 of 31
VWCE
Tbio
Novelty: 0.09328341
p_int: 0.999946373
p_ni: 0.000053627
Data Source: BioPlex
EFEMP1
Tbio
Novelty: 0.00574779
p_int: 0.999679927
p_ni: 0.000320073
Data Source: BioPlex
ZNF324B
Tdark
Family: TF
Novelty: 1.89922228
p_int: 0.998640214
p_ni: 0.001358116
p_wrong: 0.00000167
Data Source: BioPlex
ZNF550
Tdark
Family: TF
Novelty: 18
p_int: 0.998316161
p_ni: 0.001683174
p_wrong: 6.65e-7
Data Source: BioPlex
TRIM28
Tbio
Family: Epigenetic
Novelty: 0.00778381
p_int: 0.998040751
p_ni: 0.001957408
p_wrong: 0.000001842
Score: 0.925
Data Source: BioPlex,STRINGDB
GPR156
Tdark
Family: GPCR
Novelty: 0.39183023
p_int: 0.990225085
p_ni: 0.002275727
p_wrong: 0.007499187
Data Source: BioPlex
PRG2
Tbio
Novelty: 0.00548995
p_int: 0.988028655
p_ni: 0.011971344
p_wrong: 2e-9
Score: 0.167
Data Source: BioPlex,STRINGDB
SDC2
Tbio
Novelty: 0.00597758
p_int: 0.981279433
p_ni: 0.018720315
p_wrong: 2.51e-7
Data Source: BioPlex
RPF1
Tdark
Novelty: 3.67047505
p_int: 0.980391154
p_ni: 0.019605059
p_wrong: 0.000003787
Data Source: BioPlex
ZNF264
Tdark
Family: TF
Novelty: 0.32927591
p_int: 0.97868185
p_ni: 0.021317515
p_wrong: 6.35e-7
Score: 0.313
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  0.80

PubMed score by year
PubTator Score  0.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer