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Tbio
ZNF268
Zinc finger protein 268

Protein Summary
Description
Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression. Isoform 2: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228289
  • ENSP00000228289
  • ENSG00000090612
  • ENST00000536435
  • ENSP00000444412
  • ENST00000539248
  • ENSP00000467781
  • ENST00000588312
  • ENSP00000466622

Symbol
  • HZF3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.83
tissue
0.63
tissue sample
0.63
microRNA
0.61
cell line
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.97   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.97   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (10)
SLC9A8
Tbio
Family:  Transporter
Novelty:  0.03305341
p_int:  0.999999937
p_ni:  6e-8
p_wrong:  2e-9
Data Source:  BioPlex
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
p_int:  0.999996036
p_ni:  0.000003952
p_wrong:  1.1e-8
Score:  0.538
Data Source:  BioPlex,STRINGDB
TRIM28
Tbio
Family:  Epigenetic
Novelty:  0.00778381
p_int:  0.99998964
p_ni:  0.000010345
p_wrong:  1.5e-8
Score:  0.937
Data Source:  BioPlex,STRINGDB
OTUD3
Tbio
Novelty:  0.11839931
p_int:  0.883668026
p_ni:  0.000179732
p_wrong:  0.116152242
Data Source:  BioPlex
KATNAL2
Tbio
Family:  Enzyme
Novelty:  0.14820091
Score:  0.62
Data Source:  STRINGDB
GATA1
Tbio
Family:  TF
Novelty:  0.00077901
Score:  0.508
Data Source:  STRINGDB
EN2
Tbio
Family:  TF
Novelty:  0.00466947
Score:  0.484
Data Source:  STRINGDB
UPF1
Tbio
Novelty:  0.00311006
Score:  0.479
Data Source:  STRINGDB
LRRC57
Tdark
Novelty:  5.85929893
Score:  0.424
Data Source:  STRINGDB
EN1
Tbio
Family:  TF
Novelty:  0.00490799
Score:  0.411
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
2
67.5
BMI-adjusted waist-hip ratio
1
1
1
61
intraocular pressure measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
67.5
BMI-adjusted waist-hip ratio
1
61
intraocular pressure measurement
1
15.8
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 268
VGNC:14421
452396
Dog
zinc finger protein 268
VGNC:48684
100686147
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 268
Dog
zinc finger protein 268
Publication Statistics
PubMed Score 11.97
PubMed score by year
PubTator Score 14.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title