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Tbio
MXD4
Max dimerization protein 4

Protein Summary
Description
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity). This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337190
  • ENSP00000337889
  • ENSG00000123933

Symbol
  • BHLHC12
  • MAD4
  • MAD4
  • MST149
  • MSTP149
  • bHLHc12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
virus perturbation
0.97
disease perturbation
0.96
kinase perturbation
0.81
PubMedID
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.84   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.84   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
56.6
monocyte count
1
1
1
21.1
high density lipoprotein cholesterol measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
56.6
monocyte count
1
21.1
high density lipoprotein cholesterol measurement
1
15.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MAX dimerization protein 4
VGNC:13102
461074
Mouse
MGI:104991
17122
Dog
MAX dimerization protein 4
VGNC:43514
100856390
Horse
MAX dimerization protein 4
VGNC:20456
100053044
Cow
MAX dimerization protein 4
VGNC:31772
541116
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MAX dimerization protein 4
Mouse
Dog
MAX dimerization protein 4
Horse
MAX dimerization protein 4
Cow
MAX dimerization protein 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14582-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Nuclear signaling by ERBB4 (R-HSA-1251985)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Nuclear signaling by ERBB4
Reactome
Signal Transduction
Reactome
Signaling by ERBB4
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Nuclear signaling by ERBB4
Signal Transduction
Signaling by ERBB4
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (22)
1 – 10 of 22
MAX
Tbio
Family:  TF
Novelty:  0.00799068
p_int:  0.999977653
p_ni:  1e-9
p_wrong:  0.000022346
Score:  0.72
Data Source:  BioPlex,STRINGDB
MLX
Tchem
Family:  TF
Novelty:  0.0059946
Score:  0.9
Data Source:  STRINGDB
MLXIPL
Tbio
Family:  TF
Novelty:  0.00357389
Score:  0.812
Data Source:  STRINGDB
MNT
Tbio
Family:  TF
Novelty:  0.0088423
Score:  0.805
Data Source:  STRINGDB
SIN3A
Tbio
Novelty:  0.00747207
Score:  0.796
Data Source:  STRINGDB
MLXIP
Tbio
Family:  TF
Novelty:  0.04454634
Score:  0.77
Data Source:  STRINGDB
NIF3L1
Tbio
Novelty:  0.15581813
Score:  0.755
Data Source:  STRINGDB
PKLR
Tbio
Family:  Kinase
Novelty:  0.00268398
Score:  0.641
Data Source:  STRINGDB
TCP10L
Tbio
Novelty:  0.24089479
Score:  0.637
Data Source:  STRINGDB
HSD17B1
Tchem
Family:  Enzyme
Novelty:  0.00313425
Score:  0.624
Data Source:  STRINGDB
Publication Statistics
PubMed Score  18.84

PubMed score by year
PubTator Score  22.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer