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Tchem
ITPR3
Inositol 1,4,5-trisphosphate receptor type 3

Protein Summary
Description
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374316
  • ENSP00000363435
  • ENSG00000096433
  • ENST00000605930
  • ENSP00000475177

Symbol
  • IP3R
  • IP3R3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
kinase perturbation
0.98
biological process
0.95
protein domain
0.92
pathway
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 634.16   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 634.16   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
1
1
0
1.1
85.9
1
1
0
1.4
76.7
self reported educational attainment
1
1
1
66.7
1
1
0
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
0
1.1
85.9
0
1.4
76.7
self reported educational attainment
1
66.7
0
1
54.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol 1,4,5-trisphosphate receptor type 3
VGNC:7896
462618
Mouse
MGI:96624
16440
Rat
RGD:2934
25679
Dog
inositol 1,4,5-trisphosphate receptor type 3
VGNC:42159
481746
Horse
inositol 1,4,5-trisphosphate receptor type 3
VGNC:19196
100053019
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol 1,4,5-trisphosphate receptor type 3
Mouse
Rat
Dog
inositol 1,4,5-trisphosphate receptor type 3
Horse
inositol 1,4,5-trisphosphate receptor type 3
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (104)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 42
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Beta-catenin independent WNT signaling
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) induces NFAT activation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Beta-catenin independent WNT signaling
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) induces NFAT activation
Gene Ontology Terms (40)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (263)
1 – 10 of 263
TESPA1
Tbio
Novelty: 0.12779533
p_int: 0.999999959
p_ni: 2.4e-8
p_wrong: 1.7e-8
Score: 0.654
Data Source: BioPlex,STRINGDB
MRVI1
Tbio
Novelty: 0.02987514
p_int: 0.99999948
p_ni: 5.2e-7
Score: 0.925
Data Source: BioPlex,STRINGDB
RAB29
Tchem
Family: Enzyme
Novelty: 0.03751616
p_int: 0.999970358
p_ni: 0.000029634
p_wrong: 9e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
FGL2
Tbio
Novelty: 0.01108434
p_int: 0.999010708
p_ni: 0.000989285
p_wrong: 6e-9
Score: 0.217
Data Source: BioPlex,STRINGDB
TNNC2
Tbio
Novelty: 0.07759506
p_int: 0.99824338
p_ni: 0.00175662
Score: 0.252
Data Source: BioPlex,STRINGDB
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.995081882
p_ni: 0.004918118
Score: 0.727
Data Source: BioPlex,STRINGDB
L3MBTL2
Tbio
Family: Epigenetic
Novelty: 0.11193867
p_int: 0.994741713
p_ni: 0.005254837
p_wrong: 0.00000345
Data Source: BioPlex
FAM19A4
Tbio
Novelty: 0.04305684
p_int: 0.991742135
p_ni: 0.008257865
Data Source: BioPlex
PPL
Tbio
Novelty: 0.00684645
p_int: 0.990482887
p_ni: 0.009517113
Score: 0.159
Data Source: BioPlex,STRINGDB
FRMD1
Tdark
Novelty: 0.96833141
p_int: 0.990259263
p_ni: 0.009740727
p_wrong: 1e-8
Score: 0.446
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  634.16

PubMed score by year
PubTator Score  714.7

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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