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Tbio
ITPR2
Inositol 1,4,5-trisphosphate receptor type 2

Protein Summary
Description
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release med ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242737
  • ENSP00000242737
  • ENSG00000123104
  • ENST00000381340
  • ENSP00000370744

Symbol
  • ANHD
  • IP3R2
  • CFAP48
  • INSP3R2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.96
kinase perturbation
0.93
trait
0.93
disease perturbation
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.03   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.03   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
4
3
5
90.9
low density lipoprotein cholesterol measurement
2
2
2
70.1
2
1
0
1.2
69.4
refractive error measurement
1
1
1
48.9
platelet crit
1
1
1
21
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
5
90.9
low density lipoprotein cholesterol measurement
2
70.1
0
1.2
69.4
refractive error measurement
1
48.9
platelet crit
1
21
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol 1,4,5-trisphosphate receptor type 2
VGNC:8425
473389
Macaque
inositol 1,4,5-trisphosphate receptor type 2
708714
Mouse
MGI:99418
16439
Rat
RGD:69649
81678
Dog
inositol 1,4,5-trisphosphate receptor type 2
VGNC:42158
486628
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol 1,4,5-trisphosphate receptor type 2
Macaque
inositol 1,4,5-trisphosphate receptor type 2
Mouse
Rat
Dog
inositol 1,4,5-trisphosphate receptor type 2
Pathways (94)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 42
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Beta-catenin independent WNT signaling
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) induces NFAT activation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Beta-catenin independent WNT signaling
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) induces NFAT activation
Gene Ontology Terms (27)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (179)
1 – 10 of 179
TESPA1
Tbio
Novelty: 0.12779533
p_int: 0.999999906
p_ni: 9.4e-8
Score: 0.183
Data Source: BioPlex,STRINGDB
MRVI1
Tbio
Novelty: 0.02987514
p_int: 0.999999849
p_ni: 1.51e-7
Score: 0.851
Data Source: BioPlex,STRINGDB
RAB29
Tchem
Family: Enzyme
Novelty: 0.03751616
p_int: 0.999968516
p_ni: 0.000031484
Score: 0.163
Data Source: BioPlex,STRINGDB
L3MBTL2
Tbio
Family: Epigenetic
Novelty: 0.11193867
p_int: 0.999684627
p_ni: 0.000315373
Data Source: BioPlex
FAM19A4
Tbio
Novelty: 0.04305684
p_int: 0.999582666
p_ni: 0.000417334
Data Source: BioPlex
RASEF
Tbio
Novelty: 0.08877022
p_int: 0.999473021
p_ni: 0.000526979
Data Source: BioPlex
CCR6
Tchem
Family: GPCR
Novelty: 0.00257933
p_int: 0.99775619
p_ni: 0.00224381
Data Source: BioPlex
TNNC2
Tbio
Novelty: 0.07759506
p_int: 0.997309483
p_ni: 0.002690517
Score: 0.278
Data Source: BioPlex,STRINGDB
PPL
Tbio
Novelty: 0.00684645
p_int: 0.992336791
p_ni: 0.007663209
Data Source: BioPlex
CACNG2
Tbio
Family: IC
Novelty: 0.00808502
p_int: 0.972770241
p_ni: 0.027229759
Score: 0.193
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  154.03

PubMed score by year
PubTator Score  51.57

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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