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Tbio
MCM6
DNA replication licensing factor MCM6

Protein Summary
Description
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264156
  • ENSP00000264156
  • ENSG00000076003

Symbol
  • Mis5
  • P105MCM
  • MCG40308
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
co-expressed gene
0.97
kinase perturbation
0.96
gene perturbation
0.94
protein domain
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.27   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.27   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1,5 anhydroglucitol measurement
1
1
0
16.9
90.6
body mass index
2
1
2
70.8
hip circumference
1
1
1
20.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1,5 anhydroglucitol measurement
0
16.9
90.6
body mass index
2
70.8
hip circumference
1
20.4
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
minichromosome maintenance complex component 6
VGNC:2010
741695
Macaque
minichromosome maintenance complex component 6
707651
Mouse
MGI:1298227
17219
Rat
RGD:61967
29685
Dog
minichromosome maintenance complex component 6
VGNC:43086
476131
Species
Name
OMA
EggNOG
Inparanoid
Chimp
minichromosome maintenance complex component 6
Macaque
minichromosome maintenance complex component 6
Mouse
Rat
Dog
minichromosome maintenance complex component 6
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14566-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the pre-replicative complex
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Assembly of the pre-replicative complex
Cell Cycle
Cell Cycle Checkpoints
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (302)
1 – 10 of 302
ASF1A
Tchem
Novelty: 0.02544466
p_int: 0.999188517
p_ni: 0.000811483
Score: 0.675
Data Source: BioPlex,STRINGDB
ASF1B
Tbio
Novelty: 0.05716701
p_int: 0.9954816
p_ni: 0.0045184
Score: 0.851
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.967116608
p_ni: 0.032883392
Score: 0.27
Data Source: BioPlex,STRINGDB
MCM3
Tbio
Novelty: 0.00593382
p_int: 0.944561808
p_ni: 0.055438192
Score: 0.999
Data Source: BioPlex,STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
p_int: 0.928386228
p_ni: 0.071613773
Score: 0.438
Data Source: BioPlex,STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
p_int: 0.926195261
p_ni: 0.073804739
Score: 0.415
Data Source: BioPlex,STRINGDB
HIST1H3A
Tbio
Novelty: 0.00991842
p_int: 0.919444181
p_ni: 0.080555819
Score: 0.413
Data Source: BioPlex,STRINGDB
SSRP1
Tbio
Family: TF
Novelty: 0.0143993
p_int: 0.881012864
p_ni: 0.118987136
Score: 0.895
Data Source: BioPlex,STRINGDB
MCM10
Tbio
Novelty: 0.0136058
p_int: 0.822595333
p_ni: 0.177404663
p_wrong: 4e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
SPIN2B
Tdark
Novelty: 0.23202718
p_int: 0.765446546
p_ni: 0.234553454
Score: 0.392
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  129.27

PubMed score by year
PubTator Score  128.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer