Tbio MCM6 DNA replication licensing factor MCM6

Protein Summary

Description

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• Q14566
• B2R6H2
• Q13504
• Q99859

Gene Name

• MCM6

Ensembl ID

• ENST00000264156
• ENSP00000264156
• ENSG00000076003

Symbol

• Mis5
• P105MCM
• MCG40308

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
co-expressed gene	0.97
kinase perturbation	0.96
gene perturbation	0.94
protein domain	0.92

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Dna Helicase / Dna Replication Licensing Factor Mcm6

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Helicase / Dna Replication Licensing Factor Mcm6

Protein / Hydrolase / Dna Replication Licensing Factor Mcm6

DTO Classes

Protein / Enzyme / Helicase / Dna Helicase / Dna Replication Licensing Factor Mcm6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.61   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 321   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.61   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (302)

Explore Interacting Targets

1 – 10 of 302

• See Interactions on String-DB

ASF1A

Tchem

Novelty:  0.02544466

p_int:  0.999188517

p_ni:  0.000811483

Score:  0.675

Data Source:  BioPlex,STRINGDB

ASF1B

Tbio

Novelty:  0.05716701

p_int:  0.9954816

p_ni:  0.0045184

Score:  0.851

Data Source:  BioPlex,STRINGDB

HIST1H2BA

Tbio

Novelty:  0.02431803

p_int:  0.967116608

p_ni:  0.032883392

Score:  0.27

Data Source:  BioPlex,STRINGDB

MCM3

Tbio

Novelty:  0.00593382

p_int:  0.944561808

p_ni:  0.055438192

Score:  0.999

Data Source:  BioPlex,STRINGDB

HIST1H4A

Tchem

Novelty:  0.00279614

p_int:  0.928386228

p_ni:  0.071613773

Score:  0.438

Data Source:  BioPlex,STRINGDB

H2AFX

Tbio

Novelty:  0.00048694

p_int:  0.926195261

p_ni:  0.073804739

Score:  0.415

Data Source:  BioPlex,STRINGDB

HIST1H3A

Tbio

Novelty:  0.00991842

p_int:  0.919444181

p_ni:  0.080555819

Score:  0.413

Data Source:  BioPlex,STRINGDB

SSRP1

Tbio

Family:  TF

Novelty:  0.0143993

p_int:  0.881012864

p_ni:  0.118987136

Score:  0.895

Data Source:  BioPlex,STRINGDB

MCM10

Tbio

Novelty:  0.0136058

p_int:  0.822595333

p_ni:  0.177404663

p_wrong:  4e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

SPIN2B

Tchem

Novelty:  0.23202718

p_int:  0.765446546

p_ni:  0.234553454

Score:  0.392

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (24)

Reactome (17)

KEGG (2)

WikiPathways (5)

Activation of ATR in response to replication stress (R-HSA-176187)

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1 – 5 of 17

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of ATR in response to replication stress	37 targets	R-HSA-176187
Reactome	Activation of the pre-replicative complex	33 targets	R-HSA-68962
Reactome	Assembly of the pre-replicative complex	69 targets	R-HSA-68867
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle Checkpoints	272 targets	R-HSA-69620

Name	Explore in Pharos	Explore in Source
Activation of ATR in response to replication stress	37 targets	R-HSA-176187
Activation of the pre-replicative complex	33 targets	R-HSA-68962
Assembly of the pre-replicative complex	69 targets	R-HSA-68867
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle Checkpoints	272 targets	R-HSA-69620

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (4)

Components (4)

Processes (4)

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1 – 4 of 4

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
ATP binding	Non-traceable Author Statement (NAS)	UniProtKB
DNA helicase activity	Inferred from Electronic Annotation (IEA)	Ensembl
single-stranded DNA binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
leukocyte count	EFO_0004308	4	4	5		93.3
neutrophil count	EFO_0004833	4	3	4		93.1
gut microbiome measurement	EFO_0007874	5	4	0	7.4	90
myeloid white cell count	EFO_0007988	2	2	2		88.7
1,5 anhydroglucitol measurement	EFO_0008009	1	1	0	16.9	85.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
leukocyte count	EFO_0004308	5		93.3
neutrophil count	EFO_0004833	4		93.1
gut microbiome measurement	EFO_0007874	0	7.4	90
myeloid white cell count	EFO_0007988	2		88.7
1,5 anhydroglucitol measurement	EFO_0008009	0	16.9	85.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
ATP-binding
Cell cycle
Complete proteome
DNA replication
DNA-binding
Glycoprotein
Helicase
Hydrolase

GWAS Trait Find Similar Targets

No Header	No Header
1,5 anhydroglucitol measurement
aspartate aminotransferase measurement
body mass index
gut microbiome measurement
hip circumference
leukocyte count
monocyte count
myeloid white cell count
neutrophil count
neutrophil percentage of leukocytes

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
hematopoietic system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	minichromosome maintenance complex component 6	VGNC:2010	741695
Macaque	minichromosome maintenance complex component 6		707651
Mouse	minichromosome maintenance complex component 6	MGI:1298227	17219
Rat	minichromosome maintenance complex component 6	RGD:61967	29685
Dog	minichromosome maintenance complex component 6	VGNC:43086	476131

Species	Name	OMA	EggNOG	Inparanoid
Chimp	minichromosome maintenance complex component 6
Macaque	minichromosome maintenance complex component 6
Mouse	minichromosome maintenance complex component 6
Rat	minichromosome maintenance complex component 6
Dog	minichromosome maintenance complex component 6

Publication Statistics

PubMed Score 132.61

PubMed score by year

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PubTator Score 128.57

PubTator score by year

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Related Publications

Text Mined References (74)

GeneRif Annotations (22)

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10

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PMID	Year	Title