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Tbio
DMC1
Meiotic recombination protein DMC1/LIM15 homolog

Protein Summary
Description
May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216024
  • ENSP00000216024
  • ENSG00000100206
  • ENST00000428462
  • ENSP00000412703

Symbol
  • DMC1H
  • LIM15
  • DMC1H
  • LIM15
  • dJ199H16.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.96
histone modification site profile
0.83
cell type or tissue
0.67
gene perturbation
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.73   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 364   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.73   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 364   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
2
2
94.8
mathematical ability
2
1
2
65
high density lipoprotein cholesterol measurement
1
1
1
41.7
triglyceride measurement
1
1
1
36
hematocrit
1
1
1
28.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
94.8
mathematical ability
2
65
high density lipoprotein cholesterol measurement
1
41.7
triglyceride measurement
1
36
hematocrit
1
28.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA meiotic recombinase 1
VGNC:5254
458831
Macaque
DNA meiotic recombinase 1
700935
Mouse
MGI:105393
13404
Rat
RGD:1307611
362960
Dog
DNA meiotic recombinase 1
VGNC:39998
608268
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA meiotic recombinase 1
Macaque
DNA meiotic recombinase 1
Mouse
Rat
Dog
DNA meiotic recombinase 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14565-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic recombination
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic recombination
Reproduction
Gene Ontology Terms (22)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (95)
1 – 10 of 95
ACTA1
Tbio
Novelty: 0.00111813
p_int: 0.999999973
p_ni: 2.7e-8
Score: 0.333
Data Source: BioPlex,STRINGDB
RAD51
Tchem
Novelty: 0.00011516
p_int: 0.999991381
p_ni: 0.000008589
p_wrong: 3e-8
Score: 0.979
Data Source: BioPlex,STRINGDB
SIRT3
Tchem
Family: Epigenetic
Novelty: 0.00101187
p_int: 0.970817021
p_ni: 0.029182979
Score: 0.31
Data Source: BioPlex,STRINGDB
POTEF
Tbio
Novelty: 0.00191599
p_int: 0.968429912
p_ni: 0.031570088
Score: 0.198
Data Source: BioPlex,STRINGDB
ZNF302
Tdark
Family: TF
Novelty: 0.54097648
p_int: 0.864281735
p_ni: 0.135717576
p_wrong: 6.89e-7
Score: 0.327
Data Source: BioPlex,STRINGDB
SVIP
Tbio
Novelty: 0.05269453
p_int: 0.831045281
p_ni: 0.090749149
p_wrong: 0.078205571
Score: 0.239
Data Source: BioPlex,STRINGDB
SPO11
Tbio
Novelty: 0.00273994
Score: 0.987
Data Source: STRINGDB
BRCA2
Tbio
Novelty: 0.0002217
Score: 0.979
Data Source: STRINGDB
PSMC3IP
Tbio
Novelty: 0.06621408
Score: 0.97
Data Source: STRINGDB
MND1
Tbio
Novelty: 0.02206181
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.73

PubMed score by year
PubTator Score  72.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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