DMC1
Meiotic recombination protein DMC1/LIM15 homolog
Protein Summary
May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
- ENST00000216024
- ENSP00000216024
- ENSG00000100206
- ENST00000428462
- ENSP00000412703
- DMC1H
- LIM15
- DMC1H
- LIM15
- dJ199H16.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
molecular function | 0.96 | ||
histone modification site profile | 0.83 | ||
cell type or tissue | 0.67 | ||
gene perturbation | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.73 (req: < 5)
Gene RIFs: 38 (req: <= 3)
Antibodies: 364 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.73 (req: >= 5)
Gene RIFs: 38 (req: > 3)
Antibodies: 364 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0