Tbio DHX8 ATP-dependent RNA helicase DHX8

Protein Summary

Description

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• Q14562

Gene Name

• DHX8

Ensembl ID

• ENST00000262415
• ENSP00000262415
• ENSG00000067596
• ENST00000650571
• ENSP00000496923

Symbol

• DDX8
• DDX8
• Dhr2
• HRH1
• PRP22
• PRPF22

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.99
interacting protein	0.97
transcription factor binding site profile	0.95
histone modification site profile	0.83

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Rna Helicase / Atp-dependent Rna Helicase Dhx8

Protein / Nucleic Acid Binding / Rna Binding Protein / Rna Helicase / Atp-dependent Rna Helicase Dhx8

DTO Classes

Protein / Enzyme / Helicase / Rna Helicase / Atp-dependent Rna Helicase Dhx8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.35   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.35   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (275)

Explore Interacting Targets

1 – 10 of 275

• See Interactions on String-DB

NKAPD1

Tdark

Novelty:  1.56979675

p_int:  0.999999814

p_ni:  1.86e-7

Score:  0.541

Data Source:  BioPlex,STRINGDB

JMJD6

Tchem

Family:  Enzyme

Novelty:  0.00305479

p_int:  0.999999653

p_ni:  3.47e-7

Data Source:  BioPlex

NUDCD1

Tbio

Novelty:  0.07471096

p_int:  0.999986615

p_ni:  0.000013385

Score:  0.175

Data Source:  BioPlex,STRINGDB

CACTIN

Tbio

Novelty:  0.03222124

p_int:  0.99998626

p_ni:  0.00001374

Score:  0.865

Data Source:  BioPlex,STRINGDB

AHCYL2

Tbio

Family:  Enzyme

Novelty:  0.08695339

p_int:  0.99974897

p_ni:  0.00025103

Data Source:  BioPlex

CRNKL1

Tbio

Novelty:  0.10274174

p_int:  0.998510915

p_ni:  0.001489085

Score:  0.999

Data Source:  BioPlex,STRINGDB

RPL26L1

Tdark

Novelty:  0.75408617

p_int:  0.99402495

p_ni:  0.00597505

Data Source:  BioPlex

SRPK1

Tchem

Family:  Kinase

Novelty:  0.01066655

p_int:  0.993422473

p_ni:  0.006577527

Score:  0.243

Data Source:  BioPlex,STRINGDB

CHCHD10

Tbio

Novelty:  0.01659548

p_int:  0.992935992

p_ni:  0.007063999

p_wrong:  1e-8

Data Source:  BioPlex

AHCYL1

Tchem

Family:  Enzyme

Novelty:  0.02176432

p_int:  0.991619736

p_ni:  0.008380264

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

KEGG (1)

WikiPathways (1)

Find Similar Targets

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Spliceosome	133 targets	path:hsa03040

Name	Explore in Pharos	Explore in Source
Spliceosome	133 targets	path:hsa03040

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (5)

Components (6)

Processes (4)

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Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
ATP-dependent 3'-5' RNA helicase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ATP-dependent RNA helicase activity	Traceable Author Statement (TAS)	ProtInc
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	2	2	2		94.9
triglyceride measurement	EFO_0004530	1	2	2		88.9
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		85.7
sleep duration	EFO_0005271	1	1	1		59

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	2		94.9
triglyceride measurement	EFO_0004530	2		88.9
apolipoprotein A 1 measurement	EFO_0004614	1		85.7
sleep duration	EFO_0005271	1		59

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
ATP-binding
Complete proteome
Helicase
Hydrolase
Isopeptide bond
mRNA processing
mRNA splicing
Nucleotide-binding
Nucleus

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
high density lipoprotein cholesterol measurement
sleep duration
triglyceride measurement

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	DEAH-box helicase 8	VGNC:9258	740465
Macaque	DEAH-box helicase 8		713228
Mouse	DEAH (Asp-Glu-Ala-His) box polypeptide 8	MGI:1306823	217207
Rat	DEAH-box helicase 8	RGD:1310723	287727
Dog	DEAH-box helicase 8	VGNC:39952	480507

Species	Name	OMA	EggNOG	Inparanoid
Chimp	DEAH-box helicase 8
Macaque	DEAH-box helicase 8
Mouse	DEAH (Asp-Glu-Ala-His) box polypeptide 8
Rat	DEAH-box helicase 8
Dog	DEAH-box helicase 8

Publication Statistics

PubMed Score 57.35

PubMed score by year

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PubTator Score 13.67

PubTator score by year

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Related Publications

Text Mined References (19)

GeneRif Annotations (5)

Items per page:

10

0 of 0

PMID	Year	Title