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Tbio
DHX8
ATP-dependent RNA helicase DHX8

Protein Summary
Description
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262415
  • ENSP00000262415
  • ENSG00000067596
  • ENST00000650571
  • ENSP00000496923

Symbol
  • DDX8
  • DDX8
  • Dhr2
  • HRH1
  • PRP22
  • PRPF22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
interacting protein
0.97
transcription factor binding site profile
0.95
histone modification site profile
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.35   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.35   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (275)
NKAPD1
Tdark
Novelty:  1.56979675
p_int:  0.999999814
p_ni:  1.86e-7
Score:  0.541
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.999999653
p_ni:  3.47e-7
Data Source:  BioPlex
NUDCD1
Tbio
Novelty:  0.07471096
p_int:  0.999986615
p_ni:  0.000013385
Score:  0.175
Data Source:  BioPlex,STRINGDB
CACTIN
Tbio
Novelty:  0.03222124
p_int:  0.99998626
p_ni:  0.00001374
Score:  0.865
Data Source:  BioPlex,STRINGDB
AHCYL2
Tbio
Family:  Enzyme
Novelty:  0.08695339
p_int:  0.99974897
p_ni:  0.00025103
Data Source:  BioPlex
CRNKL1
Tbio
Novelty:  0.10274174
p_int:  0.998510915
p_ni:  0.001489085
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.99402495
p_ni:  0.00597505
Data Source:  BioPlex
SRPK1
Tchem
Family:  Kinase
Novelty:  0.01066655
p_int:  0.993422473
p_ni:  0.006577527
Score:  0.243
Data Source:  BioPlex,STRINGDB
CHCHD10
Tbio
Novelty:  0.01659548
p_int:  0.992935992
p_ni:  0.007063999
p_wrong:  1e-8
Data Source:  BioPlex
AHCYL1
Tchem
Family:  Enzyme
Novelty:  0.02176432
p_int:  0.991619736
p_ni:  0.008380264
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
2
2
94.9
triglyceride measurement
1
2
2
88.9
apolipoprotein A 1 measurement
1
1
1
85.7
sleep duration
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
94.9
triglyceride measurement
2
88.9
apolipoprotein A 1 measurement
1
85.7
sleep duration
1
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAH-box helicase 8
VGNC:9258
740465
Macaque
DEAH-box helicase 8
713228
Mouse
MGI:1306823
217207
Rat
RGD:1310723
287727
Dog
DEAH-box helicase 8
VGNC:39952
480507
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAH-box helicase 8
Macaque
DEAH-box helicase 8
Mouse
Rat
Dog
DEAH-box helicase 8
Publication Statistics
PubMed Score 57.35
PubMed score by year
PubTator Score 13.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title