Tbio PRPSAP1 Phosphoribosyl pyrophosphate synthase-associated protein 1

Protein Summary

Description

Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.

Uniprot Accession IDs

• Q14558
• B2R6M4
• Q96H06
• PRPP synthase-associated protein 1

Gene Name

• PRPSAP1

Ensembl ID

• ENST00000446526
• ENSP00000414624
• ENSG00000161542

Symbol

• PAP39

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
virus perturbation	0.85
histone modification site profile	0.8
transcription factor binding site profile	0.78
tissue sample	0.76

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Nucleotide Kinase / Phosphoribosyl Pyrophosphate Synthase-associated Protein 1

Protein / Transferase / Kinase / Carbohydrate Kinase / Phosphoribosyl Pyrophosphate Synthase-associated Protein 1

Protein / Ligase / Phosphoribosyl Pyrophosphate Synthase-associated Protein 1

DTO Classes

Protein / Enzyme / Transferase / Phosphoribosyl Pyrophosphate Synthase-associated Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.53   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 168   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.53   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0