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Tbio
HNF4G
Hepatocyte nuclear factor 4-gamma

Protein Summary
Description
Transcription factor. Has a lower transcription activation potential than HNF4-alpha.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354370
  • ENSP00000346339
  • ENSG00000164749
  • ENST00000396423
  • ENSP00000379701

Symbol
  • NR2A2
  • NR2A2
  • NR2A3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
protein domain
0.85
microRNA
0.8
molecular function
0.76
biological process
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.35   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.35   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
3
5
95.6
4
2
0
1.1
90.5
uric acid measurement
3
2
4
84.4
hematocrit
2
2
2
69.6
hemoglobin measurement
2
2
2
65.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
5
95.6
0
1.1
90.5
uric acid measurement
4
84.4
hematocrit
2
69.6
hemoglobin measurement
2
65.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hepatocyte nuclear factor 4 gamma
VGNC:6674
472799
Macaque
hepatocyte nuclear factor 4 gamma
697750
Mouse
MGI:1353604
30942
Rat
RGD:1310102
365744
Dog
hepatocyte nuclear factor 4 gamma
VGNC:41726
487005
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hepatocyte nuclear factor 4 gamma
Macaque
hepatocyte nuclear factor 4 gamma
Mouse
Rat
Dog
hepatocyte nuclear factor 4 gamma
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
Gene Ontology Terms (11)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (53)
1 – 10 of 53
HNF1A
Tbio
Family: TF
Novelty: 0.00101291
Score: 0.959
Data Source: STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
Score: 0.901
Data Source: STRINGDB
PFKFB1
Tbio
Family: Kinase
Novelty: 0.03400219
Score: 0.75
Data Source: STRINGDB
A1CF
Tbio
Novelty: 0.04151936
Score: 0.715
Data Source: STRINGDB
B3GNT4
Tbio
Family: Enzyme
Novelty: 0.47935258
Score: 0.674
Data Source: STRINGDB
FOXA2
Tbio
Family: TF
Novelty: 0.00244521
Score: 0.64
Data Source: STRINGDB
FOXA1
Tbio
Family: TF
Novelty: 0.00235269
Score: 0.621
Data Source: STRINGDB
UBE2Q2
Tbio
Novelty: 0.12491522
Score: 0.617
Data Source: STRINGDB
PCK1
Tbio
Family: Kinase
Novelty: 0.0033726
Score: 0.613
Data Source: STRINGDB
FADS3
Tbio
Family: Enzyme
Novelty: 0.02899077
Score: 0.609
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.35

PubMed score by year
PubTator Score  13.48

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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