HNF4G
Hepatocyte nuclear factor 4-gamma
Protein Classes
Protein Summary
Transcription factor. Has a lower transcription activation potential than HNF4-alpha.
- ENST00000354370
- ENSP00000346339
- ENSG00000164749
- ENST00000396423
- ENSP00000379701
- NR2A2
- NR2A2
- NR2A3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.88 | ||
protein domain | 0.85 | ||
microRNA | 0.8 | ||
molecular function | 0.76 | ||
biological process | 0.56 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.35 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 173 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.35 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 173 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (23)
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urate measurement | 4 | 3 | 5 | 95.6 | |||||
4 | 2 | 0 | 1.1 | 90.5 | |||||
uric acid measurement | 3 | 2 | 4 | 84.4 | |||||
hematocrit | 2 | 2 | 2 | 69.6 | |||||
hemoglobin measurement | 2 | 2 | 2 | 65.6 | |||||
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urate measurement | 5 | 95.6 | |||||
0 | 1.1 | 90.5 | |||||
uric acid measurement | 4 | 84.4 | |||||
hematocrit | 2 | 69.6 | |||||
hemoglobin measurement | 2 | 65.6 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | hepatocyte nuclear factor 4 gamma | VGNC:6674 | 472799 | |||||
Macaque | hepatocyte nuclear factor 4 gamma | 697750 | ||||||
Mouse | MGI:1353604 | 30942 | ||||||
Rat | RGD:1310102 | 365744 | ||||||
Dog | hepatocyte nuclear factor 4 gamma | VGNC:41726 | 487005 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | hepatocyte nuclear factor 4 gamma | |||||
Macaque | hepatocyte nuclear factor 4 gamma | |||||
Mouse | ||||||
Rat | ||||||
Dog | hepatocyte nuclear factor 4 gamma | |||||
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (8)
Reactome (7)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Nuclear Receptor transcription pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Nuclear Receptor transcription pathway | ||||
RNA Polymerase II Transcription | ||||
Gene Ontology Terms (11)
Functions (7)
Components (1)
Processes (3)
Items per page:
10
1 – 7 of 7
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred by Curator (IC) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (53)
1 – 10 of 53
HNF1A
Family: TF
Novelty: 0.00101291
Score: 0.959
Data Source: STRINGDB
MED1
Family: Enzyme
Novelty: 0.00852082
Score: 0.901
Data Source: STRINGDB
PFKFB1
Family: Kinase
Novelty: 0.03400219
Score: 0.75
Data Source: STRINGDB
A1CF
Novelty: 0.04151936
Score: 0.715
Data Source: STRINGDB
B3GNT4
Family: Enzyme
Novelty: 0.47935258
Score: 0.674
Data Source: STRINGDB
FOXA2
Family: TF
Novelty: 0.00244521
Score: 0.64
Data Source: STRINGDB
FOXA1
Family: TF
Novelty: 0.00235269
Score: 0.621
Data Source: STRINGDB
UBE2Q2
Novelty: 0.12491522
Score: 0.617
Data Source: STRINGDB
PCK1
Family: Kinase
Novelty: 0.0033726
Score: 0.613
Data Source: STRINGDB
FADS3
Family: Enzyme
Novelty: 0.02899077
Score: 0.609
Data Source: STRINGDB
Publication Statistics
PubMed Score 16.35
PubMed score by year
PubTator Score 13.48
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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