Tchem SQLE Squalene monooxygenase

Protein Summary

Description

Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14534
• Q9UEK6

Gene Name

• SQLE

Ensembl ID

• ENST00000265896
• ENSP00000265896
• ENSG00000104549

Symbol

• ERG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
transcription factor perturbation	0.98
disease perturbation	0.95
small molecule perturbation	0.85
transcription factor binding site profile	0.75

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / Squalene Monooxygenase

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / Squalene Monooxygenase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255.36   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255.36   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 41

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1