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Tchem
SQLE
Squalene monooxygenase

Protein Summary
Description
Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265896
  • ENSP00000265896
  • ENSG00000104549

Symbol
  • ERG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.98
disease perturbation
0.95
small molecule perturbation
0.85
transcription factor binding site profile
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.06   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.06   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 41
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (41)
CHEMBL15929
Rendered image for CHEMBL15929
NB-598
Rendered image for NB-598
CHEMBL281025
Rendered image for CHEMBL281025
CHEMBL108692
Rendered image for CHEMBL108692
CHEMBL107546
Rendered image for CHEMBL107546
CHEMBL324433
Rendered image for CHEMBL324433
CHEMBL326008
Rendered image for CHEMBL326008
CHEMBL107608
Rendered image for CHEMBL107608
CHEMBL107568
Rendered image for CHEMBL107568
Protein-Protein Interactions (132)
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.994541195
p_ni:  0.00545877
p_wrong:  3.6e-8
Data Source:  BioPlex
FAF2
Tbio
Novelty:  0.03048598
p_int:  0.992964819
p_ni:  0.007035181
Score:  0.266
Data Source:  BioPlex,STRINGDB
TREML2
Tbio
Novelty:  0.05038302
p_int:  0.984727973
p_ni:  0.015268485
p_wrong:  0.000003542
Score:  0.228
Data Source:  BioPlex,STRINGDB
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.9839001
p_ni:  0.0160999
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.981704058
p_ni:  0.018295519
p_wrong:  4.23e-7
Score:  0.33
Data Source:  BioPlex,STRINGDB
CHRND
Tclin
Family:  IC
Novelty:  0.0441685
p_int:  0.974198574
p_ni:  0.025801423
p_wrong:  3e-9
Data Source:  BioPlex
P01911
Tchem
Novelty:  0.00240724
p_int:  0.972624625
p_ni:  0.027375374
p_wrong:  1e-9
Score:  0.207
Data Source:  BioPlex,STRINGDB
SLC18A1
Tchem
Family:  Transporter
Novelty:  0.01135292
p_int:  0.960656757
p_ni:  0.039339783
p_wrong:  0.000003461
Data Source:  BioPlex
PCDHGA5
Tdark
Novelty:  2.13631603
p_int:  0.960586877
p_ni:  0.039405125
p_wrong:  0.000007998
Data Source:  BioPlex
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.956801308
p_ni:  0.043198689
p_wrong:  3e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

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Find Similar Targets
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1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
10.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
10.9
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
squalene epoxidase
VGNC:789
464383
Macaque
squalene epoxidase
706764
Mouse
MGI:109296
20775
Rat
RGD:3755
29230
Dog
squalene epoxidase
VGNC:46786
608021
Species
Name
OMA
EggNOG
Inparanoid
Chimp
squalene epoxidase
Macaque
squalene epoxidase
Mouse
Rat
Dog
squalene epoxidase
Publication Statistics
PubMed Score 181.06
PubMed score by year
PubTator Score 47.92
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title