You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KRT81
Keratin, type II cuticular Hb1

Protein Summary
Description
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327741
  • ENSP00000369349
  • ENSG00000205426

Symbol
  • KRTHB1
  • MLN137
  • HB1
  • Hb-1
  • KRTHB1
  • MLN137
  • ghHkb1
  • hHAKB2-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
tissue
0.61
cell line
0.6
small molecule perturbation
0.51
interacting protein
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.8   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.8   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (64)
1 – 10 of 64
KRT86
Tbio
Novelty: 0.01021995
Score: 0.946
Data Source: STRINGDB
KRT16
Tbio
Novelty: 0.00503235
Score: 0.934
Data Source: STRINGDB
KRT34
Tbio
Novelty: 0.07747997
Score: 0.933
Data Source: STRINGDB
KRT17
Tbio
Novelty: 0.00278761
Score: 0.933
Data Source: STRINGDB
KRT14
Tbio
Novelty: 0.00088743
Score: 0.931
Data Source: STRINGDB
KRT38
Tdark
Novelty: 0.25061021
Score: 0.931
Data Source: STRINGDB
KRT15
Tbio
Novelty: 0.00351898
Score: 0.93
Data Source: STRINGDB
KRT32
Tdark
Novelty: 1.12077627
Score: 0.93
Data Source: STRINGDB
KRT80
Tbio
Novelty: 0.08480792
Score: 0.929
Data Source: STRINGDB
KRT37
Tdark
Novelty: 0.01643723
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.80

PubMed score by year
PubTator Score  48.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer