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Tbio
HLTF
Helicase-like transcription factor

Protein Summary
Description
Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310053
  • ENSP00000308944
  • ENSG00000071794
  • ENST00000392912
  • ENSP00000376644
  • ENST00000494055
  • ENSP00000420429

Symbol
  • HIP116A
  • RNF80
  • SMARCA3
  • SNF2L3
  • ZBU1
  • ZBU1
  • HLTF1
  • RNF80
  • HIP116
  • SNF2L3
  • HIP116A
  • SMARCA3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein complex
1
protein domain
0.99
interacting protein
0.94
virus perturbation
0.9


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.01   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.01   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
helicase like transcription factor
VGNC:1837
460766
Macaque
helicase like transcription factor
712415
Mouse
MGI:1196437
20585
Rat
RGD:1309031
295568
Dog
helicase like transcription factor
VGNC:50301
477106
Species
Name
OMA
EggNOG
Inparanoid
Chimp
helicase like transcription factor
Macaque
helicase like transcription factor
Mouse
Rat
Dog
helicase like transcription factor
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14527-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein ubiquitination
Name
Explore in Pharos
Explore in Source
E3 ubiquitin ligases ubiquitinate target proteins
Metabolism of proteins
Post-translational protein modification
Protein ubiquitination
Gene Ontology Terms (18)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (167)
1 – 10 of 167
PMPCA
Tbio
Family: Enzyme
Novelty: 0.01842996
p_int: 0.999899818
p_ni: 0.000100182
Score: 0.244
Data Source: BioPlex,STRINGDB
CHD1L
Tbio
Family: Enzyme
Novelty: 0.00980287
p_int: 0.989252471
p_ni: 0.010747529
Score: 0.825
Data Source: BioPlex,STRINGDB
APLF
Tbio
Novelty: 0.01347476
p_int: 0.988885483
p_ni: 0.011114517
Score: 0.843
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.795740069
p_ni: 0.204259931
Score: 0.312
Data Source: BioPlex,STRINGDB
UBE2V2
Tbio
Novelty: 0.01112479
Score: 0.996
Data Source: Reactome,STRINGDB
RAD18
Tbio
Family: Enzyme
Novelty: 0.00519213
Score: 0.994
Data Source: Reactome,STRINGDB
PCNA
Tchem
Novelty: 0.03909539
Score: 0.991
Data Source: Reactome,STRINGDB
UBE2N
Tbio
Novelty: 0.00620946
Score: 0.989
Data Source: Reactome,STRINGDB
S100A10
Tbio
Novelty: 0.00281525
Score: 0.985
Data Source: STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  95.01

PubMed score by year
PubTator Score  53.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer