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Tbio
HIC1
Hypermethylated in cancer 1 protein

Protein Summary
Description
Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the partici ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322941
  • ENSP00000314080
  • ENSG00000177374
  • ENST00000399849
  • ENSP00000382742
  • ENST00000619757
  • ENSP00000477858

Symbol
  • ZBTB29
  • hic-1
  • ZBTB29
  • ZNF901
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor binding site profile
0.85
transcription factor
0.8
biological process
0.77
PubMedID
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.75   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.75   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
2
1
1
1.1
67.3
platelet crit
2
1
2
63.1
mean corpuscular volume
1
1
1
47.4
platelet count
1
1
1
33.7
bone density
1
1
1
19.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
1.1
67.3
platelet crit
2
63.1
mean corpuscular volume
1
47.4
platelet count
1
33.7
bone density
1
19.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1338010
15248
Rat
RGD:6488990
100912068
Dog
HIC ZBTB transcriptional repressor 1
VGNC:41683
491198
Cow
HIC ZBTB transcriptional repressor 1
VGNC:29845
786191
Pig
HIC ZBTB transcriptional repressor 1
100525779
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
HIC ZBTB transcriptional repressor 1
Cow
HIC ZBTB transcriptional repressor 1
Pig
HIC ZBTB transcriptional repressor 1
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of transcription factors
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of transcription factors
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (84)
1 – 10 of 84
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.974
Data Source: STRINGDB
UBE2I
Tbio
Novelty: 0.00267883
Score: 0.948
Data Source: Reactome,STRINGDB
PIAS1
Tbio
Family: TF
Novelty: 0.00987743
Score: 0.937
Data Source: STRINGDB
SUMO1
Tbio
Novelty: 0.00137629
Score: 0.922
Data Source: Reactome,STRINGDB
SIRT1
Tchem
Family: Epigenetic
Novelty: 0.00022265
Score: 0.91
Data Source: STRINGDB
NFKBIB
Tbio
Novelty: 0.00517222
Score: 0.908
Data Source: STRINGDB
CTBP2
Tchem
Novelty: 0.00538964
Score: 0.756
Data Source: STRINGDB
CTBP1
Tbio
Novelty: 0.00243818
Score: 0.708
Data Source: STRINGDB
RASSF1
Tbio
Novelty: 0.00137149
Score: 0.707
Data Source: STRINGDB
ARID1A
Tbio
Family: TF
Novelty: 0.00232025
Score: 0.696
Data Source: STRINGDB
Publication Statistics
PubMed Score  149.75

PubMed score by year
PubTator Score  98.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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