Tbio NEDD9 Enhancer of filamentation 1

Protein Summary

Description

Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form. The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• Q14511
• A8K9G7
• A8MSJ9
• G5E9Y9
• Q5T9R4
• Q5XKI0
• hEF1

Gene Name

• NEDD9

Ensembl ID

• ENST00000379433
• ENSP00000368745
• ENSG00000111859
• ENST00000379446
• ENSP00000368759
• ENST00000504387
• ENSP00000422871

Symbol

• CASL
• CASS2
• CAS2
• CASL
• HEF1
• CAS-L
• CASS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
disease perturbation	0.99
kinase perturbation	0.99
hub protein	0.95
PubMedID	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.1   (req: < 5)

Gene RIFs: 97   (req: <= 3)

Antibodies: 321   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.1   (req: >= 5)

Gene RIFs: 97   (req: > 3)

Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0