Tchem KCNJ12 ATP-sensitive inward rectifier potassium channel 12

Protein Summary

Description

Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14500
• O43401
• Q15756
• Q8NG63

Gene Name

• KCNJ12

Ensembl ID

• ENST00000331718
• ENSP00000328150
• ENSG00000184185
• ENST00000583088
• ENSP00000463778

Symbol

• IRK2
• KCNJN1
• IRK2
• hIRK
• IRK-2
• hIRK1
• KCNJN1
• Kir2.2
• Kir2.2v
• kcnj12x
• hkir2.2x

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.84
protein domain	0.73
tissue sample	0.65
cell type or tissue	0.62
tissue	0.62

Protein Classes

DTO Classes

Protein / Ion Channel / Inward Rectifier-type Potassium Channel Family / Kcnj12 Subfamily / Atp-sensitive Inward Rectifier Potassium Channel 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.24   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 213   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.24   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0