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Tchem
KCNJ12
ATP-sensitive inward rectifier potassium channel 12

Protein Summary
Description
Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is locat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331718
  • ENSP00000328150
  • ENSG00000184185
  • ENST00000583088
  • ENSP00000463778

Symbol
  • IRK2
  • KCNJN1
  • IRK2
  • hIRK
  • IRK-2
  • hIRK1
  • KCNJN1
  • Kir2.2
  • Kir2.2v
  • kcnj12x
  • hkir2.2x
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
protein domain
0.73
tissue sample
0.65
cell type or tissue
0.62
tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.24   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.24   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0