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Tbio
RBM39
RNA-binding protein 39

Protein Summary
Description
Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process. This gene encodes a member of the U2AF65 family of proteins. The encoded protein is found in the nucleus, where it co-localizes with core spliceosomal proteins. It has been shown to play a role in both steroid hormone receptor-mediated transcription and alternative splicing, and it is also a transcriptional coregulator of the viral oncoprotein v-Rel. Multiple transcript variants have been observed for this gene. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253363
  • ENSP00000253363
  • ENSG00000131051
  • ENST00000361162
  • ENSP00000354437
  • ENST00000528062
  • ENSP00000436747

Symbol
  • HCC1
  • RNPC2
  • HCC1
  • CAPER
  • RNPC2
  • FSAP59
  • CAPERalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
1
transcription factor binding site profile
0.99
drug perturbation
0.96
ligand (protein) perturbation
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.74   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.74   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
1
3
97.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
97.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2157953
170791
Rat
RGD:1310071
362251
Dog
RNA binding motif protein 39
VGNC:45420
477216
Horse
RNA binding motif protein 39
VGNC:22243
100054976
Cow
RNA binding motif protein 39
VGNC:33799
508722
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
RNA binding motif protein 39
Horse
RNA binding motif protein 39
Cow
RNA binding motif protein 39
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14498-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (189)
1 – 10 of 189
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 0.959672984
p_ni: 0.040327016
Score: 0.264
Data Source: BioPlex,STRINGDB
SAP18
Tbio
Family: Enzyme
Novelty: 0.03918373
p_int: 0.760012009
p_ni: 0.239987991
Score: 0.711
Data Source: BioPlex,STRINGDB
U2AF2
Tbio
Novelty: 0.00590935
Score: 0.989
Data Source: STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.984
Data Source: STRINGDB
SRSF11
Tbio
Novelty: 0.17035604
Score: 0.972
Data Source: STRINGDB
PNISR
Tdark
Novelty: 0.06559175
Score: 0.965
Data Source: STRINGDB
SF3B1
Tbio
Novelty: 0.0128965
Score: 0.922
Data Source: STRINGDB
SNRNP70
Tbio
Novelty: 0.00116631
Score: 0.868
Data Source: STRINGDB
SREK1
Tbio
Novelty: 0.19228162
Score: 0.864
Data Source: STRINGDB
RBM25
Tbio
Novelty: 0.05557892
Score: 0.837
Data Source: STRINGDB
Publication Statistics
PubMed Score  30.74

PubMed score by year
PubTator Score  31.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer