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Tbio
NFE2L1
Endoplasmic reticulum membrane sensor NFE2L1

Protein Summary
Description
Endoplasmic reticulum membrane sensor NFE2L1: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (PubMed:20932482, PubMed:24448410). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (PubMed:20932482). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity). Involved in proteasome h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357480
  • ENSP00000350072
  • ENSG00000082641
  • ENST00000362042
  • ENSP00000354855
  • ENST00000585291
  • ENSP00000461960

Symbol
  • HBZ17
  • NRF1
  • TCF11
  • NRF1
  • TCF11
  • LCR-F1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.96
transcription factor binding site profile
0.94
molecular function
0.88
transcription factor
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.22   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.22   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
MAFF
Tbio
Family:  TF
Novelty:  0.01974936
p_int:  1
Score:  0.837
Data Source:  BioPlex,STRINGDB
KEAP1
Tclin
Novelty:  0.00062812
Score:  0.974
Data Source:  STRINGDB
MAFG
Tbio
Family:  TF
Novelty:  0.01605125
Score:  0.905
Data Source:  STRINGDB
MAFK
Tbio
Family:  TF
Novelty:  0.01735942
Score:  0.89
Data Source:  STRINGDB
NRF1
Tbio
Family:  TF
Novelty:  0.00543248
Score:  0.81
Data Source:  STRINGDB
APRG1
Tdark
Novelty:  0.53797468
Score:  0.755
Data Source:  STRINGDB
GCLC
Tchem
Family:  Enzyme
Novelty:  0.00217206
Score:  0.751
Data Source:  STRINGDB
TBKBP1
Tbio
Family:  Enzyme
Novelty:  0.11778482
Score:  0.697
Data Source:  STRINGDB
PRR15L
Tdark
Novelty:  1.42586739
Score:  0.696
Data Source:  STRINGDB
OSBPL7
Tbio
Novelty:  0.2696624
Score:  0.694
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (37)
Find Similar Targets
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
4
80.1
triglyceride measurement
3
2
3
75.4
hemoglobin measurement
1
1
1
72.9
BMI-adjusted hip circumference
2
2
3
66.6
hematocrit
1
1
1
63.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
80.1
triglyceride measurement
3
75.4
hemoglobin measurement
1
72.9
BMI-adjusted hip circumference
3
66.6
hematocrit
1
63.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear factor, erythroid 2 like 1
VGNC:9473
455185
Macaque
nuclear factor, erythroid 2 like 1
695404
Mouse
MGI:99421
18023
Dog
nuclear factor, erythroid 2 like 1
VGNC:43772
403692
Cow
nuclear factor, erythroid 2 like 1
VGNC:32035
534582
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear factor, erythroid 2 like 1
Macaque
nuclear factor, erythroid 2 like 1
Mouse
Dog
nuclear factor, erythroid 2 like 1
Cow
nuclear factor, erythroid 2 like 1
Publication Statistics
PubMed Score 75.22
PubMed score by year
PubTator Score 28.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title