NFE2L1
Endoplasmic reticulum membrane sensor NFE2L1
Protein Summary
Endoplasmic reticulum membrane sensor NFE2L1: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (PubMed:20932482, PubMed:24448410). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (PubMed:20932482). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity). Involved in proteasome h ...more
- ENST00000357480
- ENSP00000350072
- ENSG00000082641
- ENST00000362042
- ENSP00000354855
- ENST00000585291
- ENSP00000461960
- HBZ17
- NRF1
- TCF11
- NRF1
- TCF11
- LCR-F1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 0.96 | ||
transcription factor binding site profile | 0.94 | ||
molecular function | 0.88 | ||
transcription factor | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 75.22 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 217 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 75.22 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 217 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 30
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (81)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (37)
Functions (14)
Components (7)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 4 | 4 | 80.1 | |||||
triglyceride measurement | 3 | 2 | 3 | 75.4 | |||||
hemoglobin measurement | 1 | 1 | 1 | 72.9 | |||||
BMI-adjusted hip circumference | 2 | 2 | 3 | 66.6 | |||||
hematocrit | 1 | 1 | 1 | 63.4 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 4 | 80.1 | |||||
triglyceride measurement | 3 | 75.4 | |||||
hemoglobin measurement | 1 | 72.9 | |||||
BMI-adjusted hip circumference | 3 | 66.6 | |||||
hematocrit | 1 | 63.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | nuclear factor, erythroid 2 like 1 | VGNC:9473 | 455185 | |||||
Macaque | nuclear factor, erythroid 2 like 1 | 695404 | ||||||
Mouse | MGI:99421 | 18023 | ||||||
Dog | nuclear factor, erythroid 2 like 1 | VGNC:43772 | 403692 | |||||
Cow | nuclear factor, erythroid 2 like 1 | VGNC:32035 | 534582 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | nuclear factor, erythroid 2 like 1 | |||||
Macaque | nuclear factor, erythroid 2 like 1 | |||||
Mouse | ||||||
Dog | nuclear factor, erythroid 2 like 1 | |||||
Cow | nuclear factor, erythroid 2 like 1 | |||||
Publication Statistics
PubMed Score 75.22
PubMed score by year
PubTator Score 28.37
PubTator score by year
Related Publications
Text Mined References (51)
GeneRif Annotations (28)
Items per page:
0 of 0
PMID | Year | Title |
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