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Tbio
SLBP
Histone RNA hairpin-binding protein

Protein Summary
Description
RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression. Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds to the 5' side of the stem-loop structure of histone pre-mRNAs. This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000429429
  • ENSP00000406322
  • ENSG00000163950
  • ENST00000489418
  • ENSP00000417686

Symbol
  • HBP
  • HBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.97
kinase perturbation
0.96
ligand (protein) perturbation
0.96
transcription factor perturbation
0.91
transcription factor binding site profile
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.22   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.22   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (205)
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.999992292
p_ni:  0.000004018
p_wrong:  0.000003691
Score:  0.177
Data Source:  BioPlex,STRINGDB
NDOR1
Tbio
Family:  Enzyme
Novelty:  0.07400532
p_int:  0.999981049
p_ni:  0.000012129
p_wrong:  0.000006823
Data Source:  BioPlex
ZFC3H1
Tbio
Novelty:  0.17313739
p_int:  0.999973154
p_ni:  0.000013797
p_wrong:  0.000013048
Score:  0.244
Data Source:  BioPlex,STRINGDB
GSTM3
Tbio
Family:  Enzyme
Novelty:  0.0078192
p_int:  0.989009236
p_ni:  0.000034424
p_wrong:  0.01095634
Score:  0.237
Data Source:  BioPlex,STRINGDB
ERI1
Tbio
Family:  Enzyme
Novelty:  0.00959105
Score:  0.998
Data Source:  STRINGDB
LSM10
Tbio
Novelty:  0.16403413
Score:  0.99
Data Source:  STRINGDB
LSM11
Tbio
Novelty:  0.10694492
Score:  0.986
Data Source:  STRINGDB
MIF4GD
Tbio
Novelty:  0.04798623
Score:  0.984
Data Source:  STRINGDB
NASP
Tbio
Novelty:  0.00902599
Score:  0.984
Data Source:  STRINGDB
ZNF473
Tbio
Family:  TF
Novelty:  0.07957644
Score:  0.975
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
6
3
3
1.1
94.3
urinary bladder carcinoma
4
2
0
1.2
93.5
BMI-adjusted hip circumference
4
10
11
92.5
2
2
0
1.1
67.6
body height
1
1
1
62.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
3
1.1
94.3
urinary bladder carcinoma
0
1.2
93.5
BMI-adjusted hip circumference
11
92.5
0
1.1
67.6
body height
1
62.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stem-loop binding protein
VGNC:49205
471120
Macaque
stem-loop binding protein
722546
Mouse
MGI:108402
20492
Rat
RGD:1584682
681062
Dog
stem-loop binding protein
VGNC:46210
488810
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stem-loop binding protein
Macaque
stem-loop binding protein
Mouse
Rat
Dog
stem-loop binding protein
Publication Statistics
PubMed Score 157.22
PubMed score by year
PubTator Score 63.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title