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Tbio
BECN1
Beclin-1

Protein Summary
Description
Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense. Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors. Thi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361523
  • ENSP00000355231
  • ENSG00000126581
  • ENST00000590099
  • ENSP00000465364

Symbol
  • GT197
  • ATG6
  • VPS30
  • beclin1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
1
biological process
0.99
kinase perturbation
0.98
chemical
0.89


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2763.44   (req: < 5)
Gene RIFs: 351   (req: <= 3)
Antibodies: 1395   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2763.44   (req: >= 5)
Gene RIFs: 351   (req: > 3)
Antibodies: 1395   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beclin 1
VGNC:9222
454700
Macaque
beclin 1
711649
Mouse
MGI:1891828
56208
Rat
RGD:620190
114558
Dog
beclin 1
480513
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beclin 1
Macaque
beclin 1
Mouse
Rat
Dog
beclin 1
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14457-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Deubiquitination
Reactome
Macroautophagy
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Deubiquitination
Macroautophagy
Metabolism of proteins
Gene Ontology Terms (66)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (385)
1 – 10 of 385
ATG14
Tbio
Novelty: 0.00914791
p_int: 0.99999999
p_ni: 7e-9
p_wrong: 4e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RUBCNL
Tbio
Novelty: 0.20019585
p_int: 0.999999975
p_ni: 1.6e-8
p_wrong: 9e-9
Score: 0.521
Data Source: BioPlex,STRINGDB
NRBF2
Tbio
Novelty: 0.02432243
p_int: 0.999999967
p_ni: 3.1e-8
p_wrong: 2e-9
Score: 0.974
Data Source: BioPlex,STRINGDB
SYCE1
Tbio
Novelty: 0.05038876
p_int: 0.999990392
p_ni: 0.000008638
p_wrong: 9.69e-7
Data Source: BioPlex
UVRAG
Tbio
Novelty: 0.01081083
Score: 0.999
Data Source: Reactome,STRINGDB
PIK3R4
Tbio
Family: Kinase
Novelty: 0.01412698
Score: 0.999
Data Source: Reactome,STRINGDB
PIK3C3
Tchem
Family: Kinase
Novelty: 0.00269825
Score: 0.999
Data Source: Reactome,STRINGDB
BCL2L1
Tchem
Novelty: 0.00018414
Score: 0.999
Data Source: STRINGDB
ATG3
Tbio
Novelty: 0.00541077
Score: 0.997
Data Source: STRINGDB
ATG12
Tbio
Novelty: 0.00304298
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  2763.44

PubMed score by year
PubTator Score  1282.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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