Protein Summary
Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense. Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors. Thi ...more
- ENST00000361523
- ENSP00000355231
- ENSG00000126581
- ENST00000590099
- ENSP00000465364
- GT197
- ATG6
- VPS30
- beclin1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
virus perturbation | 1 | ||
biological process | 0.99 | ||
kinase perturbation | 0.98 | ||
chemical | 0.89 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2925.26 (req: < 5)
Gene RIFs: 351 (req: <= 3)
Antibodies: 1395 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2925.26 (req: >= 5)
Gene RIFs: 351 (req: > 3)
Antibodies: 1395 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 50
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (385)
ATG14
Novelty: 0.00914791
p_int: 0.99999999
p_ni: 7e-9
p_wrong: 4e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RUBCNL
Novelty: 0.20019585
p_int: 0.999999975
p_ni: 1.6e-8
p_wrong: 9e-9
Score: 0.521
Data Source: BioPlex,STRINGDB
NRBF2
Novelty: 0.02432243
p_int: 0.999999967
p_ni: 3.1e-8
p_wrong: 2e-9
Score: 0.974
Data Source: BioPlex,STRINGDB
SYCE1
Novelty: 0.05038876
p_int: 0.999990392
p_ni: 0.000008638
p_wrong: 9.69e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (16)
Reactome (7)
KEGG (6)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Autophagy | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Deubiquitination | ||||
Reactome | Macroautophagy | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Autophagy | ||||
Cellular responses to external stimuli | ||||
Deubiquitination | ||||
Macroautophagy | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (66)
Functions (5)
Components (16)
Processes (45)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 4 | 4 | 76.6 | |||||
waist-hip ratio | 1 | 3 | 3 | 72.9 | |||||
waist circumference | 1 | 2 | 2 | 43.8 | |||||
triglyceride measurement | 1 | 1 | 1 | 33.1 | |||||
2 | 1 | 1 | 1.1 | 26.1 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 4 | 76.6 | |||||
waist-hip ratio | 3 | 72.9 | |||||
waist circumference | 2 | 43.8 | |||||
triglyceride measurement | 1 | 33.1 | |||||
1 | 1.1 | 26.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | beclin 1 | VGNC:9222 | 454700 | |||||
Macaque | beclin 1 | 711649 | ||||||
Mouse | MGI:1891828 | 56208 | ||||||
Rat | RGD:620190 | 114558 | ||||||
Dog | beclin 1 | 480513 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | beclin 1 | |||||
Macaque | beclin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | beclin 1 | |||||
Publication Statistics
PubMed Score 2925.26
PubMed score by year
PubTator Score 1282.55
PubTator score by year
Related Publications
Text Mined References (410)
GeneRif Annotations (351)
Items per page:
0 of 0
PMID | Year | Title |
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