Tchem GRB7 Growth factor receptor-bound protein 7

Protein Summary

Description

Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• Q14451
• B2RAV1
• B3KNL0
• B3KWP9
• B7WP75
• J3KQM4
• Q53YD3
• Q92568
• Q96DF9
• Q9Y220

Gene Name

• GRB7

Ensembl ID

• ENST00000309156
• ENSP00000310771
• ENSG00000141738
• ENST00000394204
• ENSP00000377754
• ENST00000394209
• ENSP00000377759
• ENST00000394211
• ENSP00000377761
• ENST00000445327
• ENSP00000403459

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
PubMedID	0.81
hub protein	0.79
small molecule perturbation	0.77
transcription factor	0.74

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Growth Factor Receptor-bound Protein 7

DTO Classes

Protein / Receptor / Growth Factor Receptor-bound Protein 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.1   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 326   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.1   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0