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Tbio
GRB7
Growth factor receptor-bound protein 7

Protein Summary
Description
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309156
  • ENSP00000310771
  • ENSG00000141738
  • ENST00000394204
  • ENSP00000377754
  • ENST00000394209
  • ENSP00000377759
  • ENST00000394211
  • ENSP00000377761
  • ENST00000445327
  • ENSP00000403459
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
PubMedID
0.81
hub protein
0.79
small molecule perturbation
0.77
transcription factor
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.1   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.1   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
18.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
18.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth factor receptor bound protein 7
VGNC:9310
454637
Macaque
growth factor receptor bound protein 7
697951
Mouse
MGI:102683
14786
Rat
RGD:619759
84427
Dog
growth factor receptor bound protein 7
VGNC:41473
491021
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth factor receptor bound protein 7
Macaque
growth factor receptor bound protein 7
Mouse
Rat
Dog
growth factor receptor bound protein 7
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14451-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cell surface interactions at the vascular wall
Reactome
Developmental Biology
Reactome
Downstream signal transduction
Reactome
GRB7 events in ERBB2 signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Cell surface interactions at the vascular wall
Developmental Biology
Downstream signal transduction
GRB7 events in ERBB2 signaling
Protein-Protein Interactions (102)
1 – 10 of 102
ERBB2
Tclin
Family: Kinase
Novelty: 0.00003761
Score: 0.991
Data Source: Reactome,STRINGDB
PTK2
Tclin
Family: Kinase
Novelty: 0.00066622
Score: 0.979
Data Source: STRINGDB
EPHB1
Tchem
Family: Kinase
Novelty: 0.01424716
Score: 0.962
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.957
Data Source: STRINGDB
KIT
Tclin
Family: Kinase
Novelty: 0.00011237
Score: 0.953
Data Source: Reactome,STRINGDB
PDGFRB
Tclin
Family: Kinase
Novelty: 0.00074896
Score: 0.952
Data Source: Reactome,STRINGDB
RET
Tclin
Family: Kinase
Novelty: 0.00028324
Score: 0.95
Data Source: Reactome,STRINGDB
TEK
Tclin
Family: Kinase
Novelty: 0.00079268
Score: 0.943
Data Source: Reactome,STRINGDB
RND1
Tbio
Family: Enzyme
Novelty: 0.00834946
Score: 0.941
Data Source: STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  111.10

PubMed score by year
PubTator Score  97.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer