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Tbio
GRB14
Growth factor receptor-bound protein 14

Protein Summary
Description
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263915
  • ENSP00000263915
  • ENSG00000115290
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.87
protein domain
0.85
gene perturbation
0.73
cellular component
0.72
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.4   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.4   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (84)
1 – 10 of 84
EPDR1
Tbio
Novelty:  0.03597825
p_int:  0.99996126
p_ni:  0.000038736
p_wrong:  4e-9
Data Source:  BioPlex
CFB
Tchem
Novelty:  0.00102672
p_int:  0.844040213
p_ni:  0.024849501
p_wrong:  0.131110286
Data Source:  BioPlex
INSR
Tclin
Family:  Kinase
Novelty:  0.00230617
Score:  0.992
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.973
Data Source:  STRINGDB
TEK
Tclin
Family:  Kinase
Novelty:  0.00079268
Score:  0.967
Data Source:  Reactome,STRINGDB
PRKCZ
Tchem
Family:  Kinase
Novelty:  0.00201366
Score:  0.962
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.928
Data Source:  STRINGDB
AKT2
Tchem
Family:  Kinase
Novelty:  0.00167027
Score:  0.913
Data Source:  STRINGDB
ANGPT1
Tbio
Novelty:  0.00115408
Score:  0.91
Data Source:  Reactome,STRINGDB
SGK1
Tchem
Family:  Kinase
Novelty:  0.00155681
Score:  0.905
Data Source:  STRINGDB
Pathways (9)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
Tie2 Signaling
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Tie2 Signaling
GWAS Traits (44)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
11
37
69
99.8
waist-hip ratio
3
31
33
99.8
triglyceride measurement
10
9
14
2
99
waist circumference
2
17
18
99
BMI-adjusted waist circumference
7
17
21
98.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
69
99.8
waist-hip ratio
33
99.8
triglyceride measurement
14
2
99
waist circumference
18
99
BMI-adjusted waist circumference
21
98.7
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth factor receptor bound protein 14
VGNC:1952
459695
Macaque
growth factor receptor bound protein 14
707075
Mouse
MGI:1355324
50915
Rat
RGD:61869
58844
Dog
growth factor receptor bound protein 14
VGNC:41471
478770
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth factor receptor bound protein 14
Macaque
growth factor receptor bound protein 14
Mouse
Rat
Dog
growth factor receptor bound protein 14
Publication Statistics
PubMed Score 47.40
PubMed score by year
PubTator Score 38.48
PubTator score by year