Tbio CAPRIN1 Caprin-1

Protein Summary

Description

May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.

Uniprot Accession IDs

• Q14444
• A6NMY7
• D3DR06
• Q15074
• Q6IMN4
• Q6IMN7
• Q9BV09

Gene Name

• CAPRIN1

Ensembl ID

• ENST00000341394
• ENSP00000340329
• ENSG00000135387
• ENST00000389645
• ENSP00000374296
• ENST00000530820
• ENSP00000434204
• ENST00000532820
• ENSP00000434150

Symbol

• GPIAP1
• GPIP137
• M11S1
• RNG105
• M11S1
• GPIAP1
• RNG105
• GPIP137
• GRIP137
• p137GPI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.99
disease perturbation	0.95
interacting protein	0.95
transcription factor perturbation	0.94
kinase perturbation	0.91

Protein Classes

PANTHER Classes

Protein / Transporter / Caprin-1

DTO Classes

Protein / Transporter / Caprin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.7   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 287   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.7   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0