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Tbio
PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

Protein Summary
Description
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216452
  • ENSP00000216452
  • ENSG00000100564

Symbol
  • GPI-H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
metabolite
0.73
tissue sample
0.66
tissue
0.61
kinase perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.63   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.63   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (7)
Metabolism of proteins (R-HSA-392499)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of glycosylphosphatidylinositol (GPI)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Synthesis of glycosylphosphatidylinositol (GPI)
Protein-Protein Interactions (56)
1 – 10 of 56
COX4I1
Tbio
Family: Enzyme
Novelty: 0.00416656
p_int: 0.999939388
p_ni: 0.000060612
Data Source: BioPlex
IL18RAP
Tbio
Novelty: 0.02250889
p_int: 0.999752038
p_ni: 0.00024796
p_wrong: 2e-9
Score: 0.485
Data Source: BioPlex,STRINGDB
P2RX4
Tchem
Family: IC
Novelty: 0.00292374
p_int: 0.999040372
p_ni: 0.00084138
p_wrong: 0.000118248
Score: 0.235
Data Source: BioPlex,STRINGDB
ARSE
Tbio
Family: Enzyme
Novelty: 0.00067857
p_int: 0.949363165
p_ni: 0.002162535
p_wrong: 0.048474299
Data Source: BioPlex
PIGP
Tbio
Family: Enzyme
Novelty: 0.01415261
p_int: 0.836992866
p_ni: 0.001149376
p_wrong: 0.161857758
Score: 0.995
Data Source: BioPlex,STRINGDB
TMEM63C
Tdark
Family: IC
Novelty: 0.01052482
p_int: 0.789938885
p_ni: 0.001238148
p_wrong: 0.208822966
Data Source: BioPlex
PIGA
Tbio
Family: Enzyme
Novelty: 0.00206685
Score: 0.998
Data Source: STRINGDB
PIGC
Tbio
Family: Enzyme
Novelty: 0.02369255
Score: 0.996
Data Source: STRINGDB
PIGQ
Tbio
Family: Enzyme
Novelty: 0.03654348
Score: 0.99
Data Source: STRINGDB
PIGL
Tbio
Family: Enzyme
Novelty: 0.00596021
Score: 0.988
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.63

PubMed score by year
PubTator Score  4.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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