Tbio GPR176 G-protein coupled receptor 176

Protein Summary

Description

Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production. Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995 [PubMed 7893747]).[supplied by OMIM, Jul 2008]

Uniprot Accession IDs

• Q14439
• B4DZ23
• H9NIL9
• J3KNC6
• Q6NXF6

Gene Name

• GPR176

Ensembl ID

• ENST00000299092
• ENSP00000299092
• ENSG00000166073
• ENST00000543580
• ENSP00000439361
• ENST00000561100
• ENSP00000453076

Symbol

• HB-954

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.82
transcription factor perturbation	0.8
kinase perturbation	0.76
trait	0.75
transcription factor binding site profile	0.66

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Purinoceptor / Probable G-protein Coupled Receptor 176

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.01   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 178   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.01   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0