You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
GPR176
G-protein coupled receptor 176

Protein Summary
Description
Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production. Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995 [PubMed 7893747]).[supplied by OMIM, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299092
  • ENSP00000299092
  • ENSG00000166073
  • ENST00000543580
  • ENSP00000439361
  • ENST00000561100
  • ENSP00000453076

Symbol
  • HB-954
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
transcription factor perturbation
0.8
kinase perturbation
0.76
trait
0.75
transcription factor binding site profile
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.41   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.41   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
49.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
49.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 176
VGNC:6582
453702
Macaque
G protein-coupled receptor 176
701115
Mouse
MGI:2685858
381413
Rat
RGD:621718
117257
Dog
G protein-coupled receptor 176
VGNC:41418
487488
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 176
Macaque
G protein-coupled receptor 176
Mouse
Rat
Dog
G protein-coupled receptor 176
Pathways (5)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (153)
1 – 10 of 153
GPR150
Tdark
Family: GPCR
Novelty: 0.91287003
Score: 0.949
Data Source: STRINGDB
GPR25
Tdark
Family: GPCR
Novelty: 0.42142701
Score: 0.945
Data Source: STRINGDB
GPR27
Tbio
Family: GPCR
Novelty: 0.164488
Score: 0.939
Data Source: STRINGDB
GPR32
Tchem
Family: GPCR
Novelty: 0.0551913
Score: 0.932
Data Source: STRINGDB
GPR20
Tdark
Family: GPCR
Novelty: 0.34435286
Score: 0.93
Data Source: STRINGDB
GPR45
Tbio
Family: GPCR
Novelty: 0.08366919
Score: 0.929
Data Source: STRINGDB
GNGT2
Tbio
Novelty: 0.0468008
Score: 0.927
Data Source: STRINGDB
MC5R
Tchem
Family: GPCR
Novelty: 0.00964499
Score: 0.924
Data Source: STRINGDB
GPR39
Tchem
Family: GPCR
Novelty: 0.01244607
Score: 0.922
Data Source: STRINGDB
GPR84
Tchem
Family: GPCR
Novelty: 0.02360587
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.41

PubMed score by year
PubTator Score  1.23

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer