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Tbio
GALNT3
Polypeptide N-acetylgalactosaminyltransferase 3

Protein Summary
Description
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis. This gene encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members, however the enzymes have different substrate specificities. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392701
  • ENSP00000376465
  • ENSG00000115339

Symbol
  • HHS
  • HFTC
  • HFTC1
  • GalNAc-T3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
kinase perturbation
0.81
histone modification site profile
0.8
cellular component
0.72
gene perturbation
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.02   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.02   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
8
7
10
94.9
1
1
1
52.4
intelligence
2
2
1
6
34.9
femoral neck bone mineral density
1
1
1
14
alkaline phosphatase measurement
1
1
0
7
12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
10
94.9
1
52.4
intelligence
1
6
34.9
femoral neck bone mineral density
1
14
alkaline phosphatase measurement
0
7
12
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polypeptide N-acetylgalactosaminyltransferase 3
VGNC:10819
459702
Macaque
polypeptide N-acetylgalactosaminyltransferase 3
707605
Mouse
MGI:894695
14425
Rat
RGD:1306443
366061
Dog
polypeptide N-acetylgalactosaminyltransferase 3
VGNC:41095
478774
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polypeptide N-acetylgalactosaminyltransferase 3
Macaque
polypeptide N-acetylgalactosaminyltransferase 3
Mouse
Rat
Dog
polypeptide N-acetylgalactosaminyltransferase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14435-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (17)
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) (R-HSA-5083625)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
FGFR3 ligand binding and activation
Name
Explore in Pharos
Explore in Source
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
FGFR3 ligand binding and activation
Protein-Protein Interactions (70)
1 – 10 of 70
RSPRY1
Tdark
Novelty:  0.26883105
p_int:  0.962269275
p_ni:  3.64e-7
p_wrong:  0.037730361
Score:  0.204
Data Source:  BioPlex,STRINGDB
FGF23
Tclin
Novelty:  0.00047318
Score:  0.991
Data Source:  Reactome,STRINGDB
C1GALT1
Tbio
Family:  Enzyme
Novelty:  0.01191596
Score:  0.958
Data Source:  STRINGDB
MUC1
Tchem
Novelty:  0.00024203
Score:  0.943
Data Source:  STRINGDB
MUC5AC
Tbio
Novelty:  0.00074159
Score:  0.934
Data Source:  STRINGDB
MUC4
Tbio
Novelty:  0.00193208
Score:  0.923
Data Source:  STRINGDB
MUC6
Tbio
Novelty:  0.00304872
Score:  0.922
Data Source:  STRINGDB
MUC7
Tbio
Novelty:  0.00750654
Score:  0.921
Data Source:  STRINGDB
MUC16
Tbio
Novelty:  0.00444587
Score:  0.915
Data Source:  STRINGDB
MUC5B
Tbio
Novelty:  0.000832
Score:  0.914
Data Source:  STRINGDB
Publication Statistics
PubMed Score  99.02

PubMed score by year
PubTator Score  78.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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