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Tclin
PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase A

Protein Summary
Description
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359062
  • ENSP00000351957
  • ENSG00000172572

Symbol
  • HTNB
  • CGI-PDE
  • CGI-PDE A
  • CGI-PDE-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.9
molecular function
0.9
ligand (protein) perturbation
0.83
histone modification site profile
0.72
gene perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.24   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.24   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 122
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10
Approved Drugs (10)
1 – 10 of 10
dipyridamole
chemical structure image
theophylline
chemical structure image
bufylline
no chemical structure image available
milrinone
chemical structure image
olprinone
chemical structure image
diprophylline
chemical structure image
cilostazol
chemical structure image
amrinone
chemical structure image
pimobendan
chemical structure image
anagrelide
chemical structure image
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
4
8
97.9
sex hormone-binding globulin measurement
4
2
4
97.4
balding measurement
1
1
1
80.9
1
1
1
59.6
myeloid white cell count
1
1
1
57.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
8
97.9
sex hormone-binding globulin measurement
4
97.4
balding measurement
1
80.9
1
59.6
myeloid white cell count
1
57.7
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 3A
VGNC:5525
465329
Macaque
phosphodiesterase 3A
704524
Mouse
MGI:1860764
54611
Rat
RGD:61942
50678
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 3A
Macaque
phosphodiesterase 3A
Mouse
Rat
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14432-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (98)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (20)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (88)
1 – 10 of 88
PDE3B
Tclin
Family: Enzyme
Novelty: 0.0088954
Score: 0.908
Data Source: STRINGDB
APRT
Tbio
Family: Enzyme
Novelty: 0.00483077
Score: 0.901
Data Source: STRINGDB
DCK
Tchem
Family: Kinase
Novelty: 0.00201831
Score: 0.9
Data Source: STRINGDB
ADK
Tchem
Family: Kinase
Novelty: 0.00196435
Score: 0.9
Data Source: STRINGDB
AK3
Tbio
Family: Kinase
Novelty: 0.02673466
Score: 0.9
Data Source: STRINGDB
ADSL
Tbio
Family: Enzyme
Novelty: 0.0028496
Score: 0.9
Data Source: STRINGDB
PRKACA
Tchem
Family: Kinase
Novelty: 0.03869658
Score: 0.81
Data Source: STRINGDB
ALDH7A1
Tbio
Family: Enzyme
Novelty: 0.00069494
Score: 0.788
Data Source: STRINGDB
NPR2
Tbio
Family: Kinase
Novelty: 0.00418989
Score: 0.785
Data Source: STRINGDB
ADCY6
Tchem
Family: Enzyme
Novelty: 0.00528765
Score: 0.763
Data Source: STRINGDB
Publication Statistics
PubMed Score  185.24

PubMed score by year
PubTator Score  107.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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