Tbio GK2 Glycerol kinase 2

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Carbohydrate Kinase / Glycerol Kinase 2

DTO Classes

Protein / Kinase / Non-protein Kinase / Other Small Molecule Kinase / Fggy Kinase Family / Glycerol Kinase 2

Protein Summary

Description

Key enzyme in the regulation of glycerol uptake and metabolism.

Uniprot Accession IDs

• Q14410
• A8K876
• Q6PD73
• Q86XV8
• GK 2

Gene Name

• GK2

Ensembl ID

• ENST00000358842
• ENSP00000351706
• ENSG00000196475

Symbol

• GKP2
• GKTA
• GKP2
• GKTA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
gene perturbation	0.81
cellular component	0.62
protein domain	0.58
co-expressed gene	0.57

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.66   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 251   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.66   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (32)

Reactome (4)

KEGG (3)

PathwayCommons (1)

UniProt (1)

WikiPathways (23)

Metabolism (R-HSA-1430728)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Triglyceride biosynthesis	14 targets	R-HSA-75109
Reactome	Triglyceride metabolism	38 targets	R-HSA-8979227

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Triglyceride biosynthesis	14 targets	R-HSA-75109
Triglyceride metabolism	38 targets	R-HSA-8979227

Gene Ontology Terms (11)

Functions (2)

Components (4)

Processes (5)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
glycerol kinase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (54)

Explore Interacting Targets

1 – 10 of 54

• See Interactions on String-DB

GK

Tbio

Family: Kinase

Novelty: 0.00835719

p_int: 0.999995109

p_ni: 3e-9

p_wrong: 0.000004888

Score: 0.807

Data Source: BioPlex,STRINGDB

HSPA8

Tchem

Novelty: 0.00100906

p_int: 0.791612387

p_ni: 0.208387613

Score: 0.295

Data Source: BioPlex,STRINGDB

GPD2

Tbio

Family: Enzyme

Novelty: 0.01150366

Score: 0.98

Data Source: STRINGDB

AKR1B10

Tchem

Family: Enzyme

Novelty: 0.00276847

Score: 0.914

Data Source: STRINGDB

AKR1A1

Tchem

Family: Enzyme

Novelty: 0.00656392

Score: 0.914

Data Source: STRINGDB

AKR1B1

Tclin

Family: Enzyme

Novelty: 0.00050572

Score: 0.914

Data Source: STRINGDB

GPAT4

Tbio

Family: Enzyme

Novelty: 0.04994969

Score: 0.912

Data Source: STRINGDB

GPAM

Tbio

Family: Enzyme

Novelty: 0.00895841

Score: 0.907

Data Source: STRINGDB

GPAT3

Tbio

Family: Enzyme

Novelty: 0.05392755

Score: 0.907

Data Source: STRINGDB

GPAT2

Tbio

Family: Enzyme

Novelty: 0.0514769

Score: 0.907

Data Source: STRINGDB

Publication Statistics

PubMed Score  6.66

PubMed score by year

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PubTator Score  26.7

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Sequence

MAAPKTAAVGPLVGAVVQGTNSTRFLVFNSKTAELLSHHKVELTQEFPKEGWVEQDPKEILQSVYECIAR

1-70

TCEKLDELNIDISNIKAVGVSNQRETTVIWDKLTGEPLYNAVVWLDLRTQTTVEDLSKKIPGNSNFVKSK

70-140

TGLPLSTYFSAVKLRWMLDNVRNVQKAVEEGRALFGTIDSWLIWSLTGGVNGGVHCTDVTNASRTMLFNI

140-210

HSLEWDKELCDFFEIPMDLLPNVFSSSEIYGLIKTGALEGVPISGCLGDQCAALVGQMCFQEGQAKNTYG

210-280

TGCFLLCNTGRKCVFSEHGLLTTVAYKLGREKPAYYALEGSVAIAGAVIRWLRDNLGIIETSGDIERLAK

280-350

EVGTSYGCYFVPAFSGLYAPYWEPSARGILCGLTQFTNKCHIAFAALEAVCFQTREILEAMNRDCGIPLR

350-420

HLQVDGGMTNNKVLMQLQADILHIPVIKPFMPETTALGAAMAAGAAEGVSVWSLEPQALSVLRMERFEPQ

420-490

IQATESEIRYATWKKAVMKSMGWVTSQSPEGGDPSIFSSLPLGFFIVSSMVMLIGARYISGVP

490-553

MAAPKTAAVGPLVGAVVQGTNSTRFLVFNSKTAELLSHHKVELTQEFPKEGWVEQDPKEILQSVYECIARTCEKLDELNIDISNIKAVGVSNQRETTVIWDKLTGEPLYNAVVWLDLRTQTTVEDLSKKIPGNSNFVKSKTGLPLSTYFSAVKLRWMLDNVRNVQKAVEEGRALFGTIDSWLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKELCDFFEIPMDLLPNVFSSSEIYGLIKTGALEGVPISGCLGDQCAALVGQMCFQEGQAKNTYGTGCFLLCNTGRKCVFSEHGLLTTVAYKLGREKPAYYALEGSVAIAGAVIRWLRDNLGIIETSGDIERLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGILCGLTQFTNKCHIAFAALEAVCFQTREILEAMNRDCGIPLRHLQVDGGMTNNKVLMQLQADILHIPVIKPFMPETTALGAAMAAGAAEGVSVWSLEPQALSVLRMERFEPQIQATESEIRYATWKKAVMKSMGWVTSQSPEGGDPSIFSSLPLGFFIVSSMVMLIGARYISGVP

Find similar targets by:

Uniprot Keyword

ATP-binding
Complete proteome
Cytoplasm
Glycerol metabolism
Kinase
Membrane
Mitochondrion
Mitochondrion outer membrane
Nucleotide-binding
Reference proteome