You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
GCKR
Glucokinase regulatory protein

Protein Summary
Description
Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity. This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000417872
  • ENSP00000398303
  • ENSG00000084734

Symbol
  • GKRP
  • FGQTL5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
disease
0.8
biological process
0.78
gene perturbation
0.73
biological term
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.59   (req: < 5)
Gene RIFs: 117   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.59   (req: >= 5)
Gene RIFs: 117   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 64
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (120)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
37
10
45
7.3
99.9
C-reactive protein measurement
8
3
11
99.7
total cholesterol measurement
11
5
15
3
99.4
sex hormone-binding globulin measurement
5
2
6
99.3
alcohol consumption measurement
12
3
13
7.4
99.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
45
7.3
99.9
C-reactive protein measurement
11
99.7
total cholesterol measurement
15
3
99.4
sex hormone-binding globulin measurement
6
99.3
alcohol consumption measurement
13
7.4
99.3
Protein Data Bank (18)
1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (249)
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) (R-HSA-5619107)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Glucose metabolism
Reactome
Glycolysis
Name
Explore in Pharos
Explore in Source
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
Disease
Disorders of transmembrane transporters
Glucose metabolism
Glycolysis
Gene Ontology Terms (17)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (83)
1 – 10 of 83
DNHD1
Tdark
Novelty: 0.96803718
p_int: 0.957079199
p_ni: 0.042920791
p_wrong: 9e-9
Data Source: BioPlex
GCK
Tchem
Family: Kinase
Novelty: 0.00112778
Score: 0.995
Data Source: Reactome,STRINGDB
TPR
Tbio
Novelty: 0.00462503
Score: 0.9
Data Source: STRINGDB
NUP205
Tbio
Novelty: 0.06778513
Score: 0.9
Data Source: STRINGDB
NUP160
Tbio
Novelty: 0.03667026
Score: 0.9
Data Source: STRINGDB
NUP107
Tbio
Novelty: 0.01994155
Score: 0.9
Data Source: STRINGDB
NUP93
Tbio
Novelty: 0.0248311
Score: 0.9
Data Source: STRINGDB
NDC1
Tbio
Novelty: 0.15840853
Score: 0.9
Data Source: STRINGDB
NUP37
Tbio
Novelty: 0.1270421
Score: 0.9
Data Source: STRINGDB
NUP155
Tbio
Novelty: 0.03884486
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  158.59

PubMed score by year
PubTator Score  148.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: