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Tbio
GAS6
Growth arrest-specific protein 6

Protein Summary
Description
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. (Microbial infection) Can bridges virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688). This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327773
  • ENSP00000331831
  • ENSG00000183087

Symbol
  • AXLLG
  • AXSF
  • AXLLG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
disease perturbation
0.97
transcription factor perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 398.55   (req: < 5)
Gene RIFs: 142   (req: <= 3)
Antibodies: 358   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 398.55   (req: >= 5)
Gene RIFs: 142   (req: > 3)
Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 81
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
4
4
99.4
triglyceride measurement
3
3
4
85.6
red blood cell distribution width
4
1
4
83.4
hematocrit
2
2
2
80.1
red blood cell density measurement
1
1
1
78.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
99.4
triglyceride measurement
4
85.6
red blood cell distribution width
4
83.4
hematocrit
2
80.1
red blood cell density measurement
1
78.1
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Gamma-carboxylation of protein precursors
Reactome
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Gamma carboxylation, hypusine formation and arylsulfatase activation
Gamma-carboxylation of protein precursors
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Hemostasis
Gene Ontology Terms (88)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (225)
1 – 10 of 225
RTBDN
Tdark
Novelty: 0.13274492
p_int: 0.999996352
p_ni: 0.000003645
p_wrong: 2e-9
Score: 0.201
Data Source: BioPlex,STRINGDB
TMEM106A
Tbio
Novelty: 0.32470607
p_int: 0.998449236
p_ni: 0.001550762
p_wrong: 3e-9
Data Source: BioPlex
LYZL2
Tdark
Family: Enzyme
Novelty: 0.50542161
p_int: 0.995224187
p_ni: 0.004775811
p_wrong: 2e-9
Data Source: BioPlex
PCDHA3
Tdark
Novelty: 0.8622898
p_int: 0.994999031
p_ni: 0.005000936
p_wrong: 3.2e-8
Data Source: BioPlex
LY86
Tbio
Novelty: 0.00314575
p_int: 0.992859447
p_ni: 0.007138441
p_wrong: 0.000002112
Score: 0.165
Data Source: BioPlex,STRINGDB
CPA2
Tbio
Family: Enzyme
Novelty: 0.01066441
p_int: 0.989600635
p_ni: 0.010399364
p_wrong: 1e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
PCDHGC5
Tdark
Novelty: 0.39651826
p_int: 0.98615811
p_ni: 0.013839471
p_wrong: 0.000002419
Data Source: BioPlex
TCTN2
Tbio
Novelty: 0.11617528
p_int: 0.984539472
p_ni: 0.015453056
p_wrong: 0.000007472
Data Source: BioPlex
PCDHB16
Tdark
Novelty: 0.67206411
p_int: 0.982703747
p_ni: 0.017213136
p_wrong: 0.000083117
Data Source: BioPlex
CLEC12A
Tbio
Novelty: 0.01478908
p_int: 0.980208658
p_ni: 0.019785208
p_wrong: 0.000006134
Data Source: BioPlex
Publication Statistics
PubMed Score  398.55

PubMed score by year
PubTator Score  250.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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