Tbio GAS6 Growth arrest-specific protein 6

Protein Summary

Description

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. (Microbial infection) Can bridges virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688). This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]

Uniprot Accession IDs

• Q14393
• B3KRQ7
• B3KVL4
• E9PBL7
• Q6IMN1
• Q7Z7N3
• GAS-6

Gene Name

• GAS6

Ensembl ID

• ENST00000327773
• ENSP00000331831
• ENSG00000183087

Symbol

• AXLLG
• AXSF
• AXLLG

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	1
protein domain	1
disease perturbation	0.97
transcription factor perturbation	0.94

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Growth Arrest-specific Protein 6

DTO Classes

Protein / Extracellular Structure / Growth Arrest-specific Protein 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 404.12   (req: < 5)

Gene RIFs: 184   (req: <= 3)

Antibodies: 358   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 404.12   (req: >= 5)

Gene RIFs: 184   (req: > 3)

Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 81

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0