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Tchem
GALE
UDP-glucose 4-epimerase

Protein Summary
Description
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids. This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374497
  • ENSP00000363621
  • ENSG00000117308
  • ENST00000617979
  • ENSP00000483375

Symbol
  • SDR1E1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
transcription factor
0.77
protein domain
0.73
transcription factor binding site profile
0.7
interacting protein
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 406.78   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 406.78   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (119)
POP5
Tbio
Family:  Enzyme
Novelty:  0.02459167
p_int:  0.998209564
p_ni:  0.00179027
p_wrong:  1.66e-7
Data Source:  BioPlex
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.996756401
p_ni:  0.003242547
p_wrong:  0.000001052
Data Source:  BioPlex
GALT
Tbio
Family:  Enzyme
Novelty:  0.0120291
Score:  0.999
Data Source:  STRINGDB
UGP2
Tbio
Family:  Enzyme
Novelty:  0.00760963
Score:  0.989
Data Source:  STRINGDB
GALK1
Tbio
Family:  Kinase
Novelty:  0.00156677
Score:  0.988
Data Source:  STRINGDB
UGDH
Tbio
Family:  Enzyme
Novelty:  0.00284931
Score:  0.987
Data Source:  STRINGDB
GALK2
Tbio
Family:  Kinase
Novelty:  0.06382824
Score:  0.985
Data Source:  STRINGDB
GALM
Tbio
Family:  Enzyme
Novelty:  0.01067063
Score:  0.962
Data Source:  STRINGDB
UAP1
Tbio
Family:  Enzyme
Novelty:  0.02034314
Score:  0.959
Data Source:  STRINGDB
B4GALT1
Tbio
Family:  Enzyme
Novelty:  0.0073693
Score:  0.916
Data Source:  STRINGDB
Pathways (17)
Defective GALE can cause Epimerase-deficiency galactosemia (EDG) (R-HSA-5609977)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective GALE can cause Epimerase-deficiency galactosemia (EDG)
Reactome
Disease
Reactome
Diseases associated with glycosylation precursor biosynthesis
Reactome
Diseases of glycosylation
Reactome
Galactose catabolism
Name
Explore in Pharos
Explore in Source
Defective GALE can cause Epimerase-deficiency galactosemia (EDG)
Disease
Diseases associated with glycosylation precursor biosynthesis
Diseases of glycosylation
Galactose catabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
4
6
92.4
eosinophil count
3
3
3
91.9
reticulocyte measurement
3
2
3
90.5
eosinophil percentage of leukocytes
2
2
2
85.5
eosinophil percentage of granulocytes
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
92.4
eosinophil count
3
91.9
reticulocyte measurement
3
90.5
eosinophil percentage of leukocytes
2
85.5
eosinophil percentage of granulocytes
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UDP-galactose-4-epimerase
VGNC:11436
456623
Macaque
UDP-galactose-4-epimerase
710553
Mouse
MGI:1921496
74246
Rat
RGD:621493
114860
Dog
UDP-galactose-4-epimerase
VGNC:41080
100855555
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UDP-galactose-4-epimerase
Macaque
UDP-galactose-4-epimerase
Mouse
Rat
Dog
UDP-galactose-4-epimerase
Publication Statistics
PubMed Score 406.78
PubMed score by year
PubTator Score 115.16
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title