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Tbio
GNA13
Guanine nucleotide-binding protein subunit alpha-13

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000439174
  • ENSP00000400717
  • ENSG00000120063
  • ENST00000541118
  • ENSP00000439647

Symbol
  • G13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor perturbation
0.91
transcription factor binding site profile
0.89
microRNA
0.86
PubMedID
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.67   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.67   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
1
1
6.5
reticulocyte measurement
1
1
1
6.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
6.5
reticulocyte measurement
1
6.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha 13
VGNC:9304
454827
Macaque
G protein subunit alpha 13
718144
Mouse
MGI:95768
14674
Rat
RGD:1310221
303634
Dog
G protein subunit alpha 13
VGNC:41298
490901
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha 13
Macaque
G protein subunit alpha 13
Mouse
Rat
Dog
G protein subunit alpha 13
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14344-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (42)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
G alpha (12/13) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
G alpha (12/13) signalling events
GPCR downstream signalling
Hemostasis
Gene Ontology Terms (32)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (214)
1 – 10 of 214
GNG3
Tbio
Novelty:  0.16941216
p_int:  0.999962055
p_ni:  0.000037945
Score:  0.957
Data Source:  BioPlex,STRINGDB
GNG2
Tbio
Novelty:  0.04807242
p_int:  0.999321619
p_ni:  0.000678381
Score:  0.961
Data Source:  BioPlex,Reactome,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
p_int:  0.9987404
p_ni:  0.001259409
p_wrong:  1.9e-7
Score:  0.95
Data Source:  BioPlex,Reactome,STRINGDB
SPSB3
Tdark
Novelty:  0.07215887
p_int:  0.998051371
p_ni:  0.000950887
p_wrong:  0.000997742
Data Source:  BioPlex
RIC8A
Tbio
Novelty:  0.01846696
p_int:  0.997767332
p_ni:  0.002232668
Score:  0.774
Data Source:  BioPlex,STRINGDB
GNG5
Tbio
Novelty:  0.1525101
p_int:  0.996820376
p_ni:  0.00317958
p_wrong:  4.4e-8
Score:  0.952
Data Source:  BioPlex,STRINGDB
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.995439416
p_ni:  0.004560584
Score:  0.959
Data Source:  BioPlex,STRINGDB
UTRN
Tchem
Novelty:  0.0018541
p_int:  0.993777738
p_ni:  0.006221862
p_wrong:  4e-7
Data Source:  BioPlex
GNGT1
Tbio
Novelty:  0.05291961
p_int:  0.988155724
p_ni:  0.011844276
Score:  0.957
Data Source:  BioPlex,STRINGDB
RNF133
Tdark
Family:  Enzyme
Novelty:  0.80255181
p_int:  0.985524774
p_ni:  0.002131952
p_wrong:  0.012343274
Data Source:  BioPlex
Publication Statistics
PubMed Score  26.67

PubMed score by year
PubTator Score  105.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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