Protein Summary
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene enc ...more
- ENST00000315323
- ENSP00000323901
- ENSG00000180340
- Fz2
- fz-2
- fzE2
- hFz2
- OMOD2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.97 | ||
transcription factor perturbation | 0.84 | ||
histone modification site profile | 0.81 | ||
biological process | 0.78 | ||
transcription factor binding site profile | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 132.13 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 331 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 132.13 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 331 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (161)
UPK1A
Novelty: 0.01748122
p_int: 0.999777299
p_ni: 0.000199697
p_wrong: 0.000023004
Data Source: BioPlex
MPPE1
Family: Enzyme
Novelty: 0.16027847
p_int: 0.998945463
p_ni: 0.001054537
Data Source: BioPlex
ADGRG5
Family: GPCR
Novelty: 0.26575982
p_int: 0.998124028
p_ni: 0.001864049
p_wrong: 0.000011923
Data Source: BioPlex
PTGIR
Family: GPCR
Novelty: 0.0091906
p_int: 0.998081501
p_ni: 0.001906689
p_wrong: 0.00001181
Data Source: BioPlex
TMPRSS11B
Family: Enzyme
Novelty: 1.20690443
p_int: 0.997583968
p_ni: 0.002407298
p_wrong: 0.000008734
Data Source: BioPlex
LAMP1
Novelty: 0.00067563
p_int: 0.997485575
p_ni: 0.002514425
Score: 0.22
Data Source: BioPlex,STRINGDB
GPR21
Family: GPCR
Novelty: 0.90865557
p_int: 0.996367898
p_ni: 0.002642975
p_wrong: 0.000989127
Data Source: BioPlex
RAMP1
Novelty: 0.00831253
p_int: 0.994816033
p_ni: 0.005179518
p_wrong: 0.00000445
Data Source: BioPlex
NRN1
Novelty: 0.01198116
p_int: 0.993222986
p_ni: 0.006315891
p_wrong: 0.000461124
Data Source: BioPlex
LYPD6
Novelty: 0.13867181
p_int: 0.980140723
p_ni: 0.019471529
p_wrong: 0.000387748
Score: 0.213
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (9)
Upstream (7)
Downstream (2)
1 – 5 of 7
Pathways (67)
Reactome (12)
KEGG (13)
PathwayCommons (32)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asymmetric localization of PCP proteins | ||||
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Ca2+ pathway | ||||
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | Disassembly of the destruction complex and recruitment of AXIN to the membrane | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asymmetric localization of PCP proteins | ||||
Beta-catenin independent WNT signaling | ||||
Ca2+ pathway | ||||
Class B/2 (Secretin family receptors) | ||||
Disassembly of the destruction complex and recruitment of AXIN to the membrane | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (4)
Components (5)
Processes (18)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | WormBase | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
platelet count | 2 | 1 | 2 | 34.7 | |||||
platelet crit | 2 | 1 | 2 | 21.4 | |||||
pulse pressure measurement | 1 | 1 | 1 | 17.2 | |||||
hip bone size | 1 | 1 | 1 | 6.2 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
platelet count | 2 | 34.7 | |||||
platelet crit | 2 | 21.4 | |||||
pulse pressure measurement | 1 | 17.2 | |||||
hip bone size | 1 | 6.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | frizzled class receptor 2 | VGNC:12141 | 454731 | |||||
Macaque | frizzled class receptor 2 | 712381 | ||||||
Mouse | MGI:1888513 | 57265 | ||||||
Rat | RGD:71012 | 64512 | ||||||
Dog | frizzled class receptor 2 | VGNC:41030 | 490937 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | frizzled class receptor 2 | |||||
Macaque | frizzled class receptor 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | frizzled class receptor 2 | |||||
Publication Statistics
PubMed Score 132.13
PubMed score by year
PubTator Score 52.17
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (38)
GeneRif Annotations (20)
Items per page:
0 of 0
PMID | Year | Title |
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