Tbio FZD2 Frizzled-2

Protein Summary

Description

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q14332
• Q0VG82
• Fz-2

Gene Name

• FZD2

Ensembl ID

• ENST00000315323
• ENSP00000323901
• ENSG00000180340

Symbol

• Fz2
• fz-2
• fzE2
• hFz2
• OMOD2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.97
transcription factor perturbation	0.84
histone modification site profile	0.81
biological process	0.78
transcription factor binding site profile	0.77

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Frizzled-2

Protein / Receptor / G-protein Coupled Receptor / Frizzled-2

Protein / ... / Protease Inhibitor / Frizzled-2

DTO Classes

Protein / G-protein Coupled Receptor / Class F Frizzled-type / Frizzled Receptor / Frizzled-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.13   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 331   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.13   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (161)

Explore Interacting Targets

1 – 10 of 161

• See Interactions on String-DB

UPK1A

Tbio

Novelty:  0.01748122

p_int:  0.999777299

p_ni:  0.000199697

p_wrong:  0.000023004

Data Source:  BioPlex

MPPE1

Tbio

Family:  Enzyme

Novelty:  0.16027847

p_int:  0.998945463

p_ni:  0.001054537

Data Source:  BioPlex

ADGRG5

Tdark

Family:  GPCR

Novelty:  0.26575982

p_int:  0.998124028

p_ni:  0.001864049

p_wrong:  0.000011923

Data Source:  BioPlex

PTGIR

Tclin

Family:  GPCR

Novelty:  0.0091906

p_int:  0.998081501

p_ni:  0.001906689

p_wrong:  0.00001181

Data Source:  BioPlex

TMPRSS11B

Tdark

Family:  Enzyme

Novelty:  1.20690443

p_int:  0.997583968

p_ni:  0.002407298

p_wrong:  0.000008734

Data Source:  BioPlex

LAMP1

Tbio

Novelty:  0.00067563

p_int:  0.997485575

p_ni:  0.002514425

Score:  0.22

Data Source:  BioPlex,STRINGDB

GPR21

Tdark

Family:  GPCR

Novelty:  0.90865557

p_int:  0.996367898

p_ni:  0.002642975

p_wrong:  0.000989127

Data Source:  BioPlex

RAMP1

Tclin

Novelty:  0.00831253

p_int:  0.994816033

p_ni:  0.005179518

p_wrong:  0.00000445

Data Source:  BioPlex

NRN1

Tbio

Novelty:  0.01198116

p_int:  0.993222986

p_ni:  0.006315891

p_wrong:  0.000461124

Data Source:  BioPlex

LYPD6

Tbio

Novelty:  0.13867181

p_int:  0.980140723

p_ni:  0.019471529

p_wrong:  0.000387748

Score:  0.213

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (9)

Explore Nearest Tclin Targets

Upstream (7)

Downstream (2)

1 – 5 of 7

RAF1

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  9

1: Gastric cancer

2: mTOR signaling pathway

3: Breast cancer

4: Signaling pathways regulating pluripotency of stem cells

more:  5 more common pathways

MAP2K1

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  10

1: Gastric cancer

2: mTOR signaling pathway

3: Cushing syndrome

4: Breast cancer

more:  6 more common pathways

BRAF

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  7

1: Gastric cancer

2: mTOR signaling pathway

3: Cushing syndrome

4: Breast cancer

more:  3 more common pathways

EGFR

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  7

1: Gastric cancer

2: Cushing syndrome

3: Breast cancer

4: Hepatocellular carcinoma

more:  3 more common pathways

MAP2K2

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  10

1: Gastric cancer

2: mTOR signaling pathway

3: Cushing syndrome

4: Breast cancer

more:  6 more common pathways

Pathways (67)

Reactome (12)

KEGG (13)

PathwayCommons (32)

WikiPathways (10)

Asymmetric localization of PCP proteins (R-HSA-4608870)

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Items per page:

5

1 – 5 of 12

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Asymmetric localization of PCP proteins	65 targets	R-HSA-4608870
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Reactome	Ca2+ pathway	61 targets	R-HSA-4086398
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	Disassembly of the destruction complex and recruitment of AXIN to the membrane	31 targets	R-HSA-4641262

Name	Explore in Pharos	Explore in Source
Asymmetric localization of PCP proteins	65 targets	R-HSA-4608870
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Ca2+ pathway	61 targets	R-HSA-4086398
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Disassembly of the destruction complex and recruitment of AXIN to the membrane	31 targets	R-HSA-4641262

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (27)

Functions (4)

Components (5)

Processes (18)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
Wnt-activated receptor activity	Inferred from Direct Assay (IDA)	WormBase
PDZ domain binding	Inferred from Physical Interaction (IPI)	UniProtKB
Wnt-protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
G protein-coupled receptor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	2	1	2		34.7
platelet crit	EFO_0007985	2	1	2		21.4
pulse pressure measurement	EFO_0005763	1	1	1		17.2
hip bone size	EFO_0004844	1	1	1		6.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	2		34.7
platelet crit	EFO_0007985	2		21.4
pulse pressure measurement	EFO_0005763	1		17.2
hip bone size	EFO_0004844	1		6.2

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Cell membrane
Complete proteome
Developmental protein
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
hip bone size
platelet count
platelet crit
pulse pressure measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
craniofacial phenotype
digestive/alimentary phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
nervous system phenotype
taste/olfaction phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	frizzled class receptor 2	VGNC:12141	454731
Macaque	frizzled class receptor 2		712381
Mouse	frizzled class receptor 2	MGI:1888513	57265
Rat	frizzled class receptor 2	RGD:71012	64512
Dog	frizzled class receptor 2	VGNC:41030	490937

Species	Name	OMA	EggNOG	Inparanoid
Chimp	frizzled class receptor 2
Macaque	frizzled class receptor 2
Mouse	frizzled class receptor 2
Rat	frizzled class receptor 2
Dog	frizzled class receptor 2

Publication Statistics

PubMed Score 132.13

PubMed score by year

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PubTator Score 52.17

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Patents

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Related Publications

Text Mined References (38)

GeneRif Annotations (20)

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PMID	Year	Title