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Tchem
GPR18
N-arachidonyl glycine receptor

Protein Summary
Description
Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937). However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161). Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24762058). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083). May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). Mediates NAGly-induced process of reorganization of ac ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340807
  • ENSP00000343428
  • ENSG00000125245
  • ENST00000397470
  • ENSP00000380610
  • ENST00000397473
  • ENSP00000380613

Symbol
  • GPCRW
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
tissue sample
0.6
gene perturbation
0.53
metabolite
0.45
pathway
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.1   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 335   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.1   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 335   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (254)
SERPINB5
Tbio
Novelty:  0.00192585
p_int:  0.998791707
p_ni:  0.001208293
Data Source:  BioPlex
HAL
Tbio
Family:  Enzyme
Novelty:  0.01504631
p_int:  0.985286646
p_ni:  0.014713354
Score:  0.549
Data Source:  BioPlex,STRINGDB
SERPINB4
Tbio
Novelty:  0.00522283
p_int:  0.939837427
p_ni:  0.060162573
Score:  0.516
Data Source:  BioPlex,STRINGDB
CALML5
Tbio
Novelty:  0.03240679
p_int:  0.939264596
p_ni:  0.060735399
p_wrong:  5e-9
Data Source:  BioPlex
SERPINB3
Tbio
Novelty:  0.00325244
p_int:  0.911584178
p_ni:  0.088415822
Score:  0.543
Data Source:  BioPlex,STRINGDB
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.907133644
p_ni:  0.09286631
p_wrong:  4.6e-8
Data Source:  BioPlex
ARG1
Tchem
Family:  Enzyme
Novelty:  0.00063728
p_int:  0.871080291
p_ni:  0.128919709
Score:  0.252
Data Source:  BioPlex,STRINGDB
ALDH3A1
Tchem
Family:  Enzyme
Novelty:  0.00592398
p_int:  0.824916821
p_ni:  0.175083179
Score:  0.211
Data Source:  BioPlex,STRINGDB
NCCRP1
Tbio
Novelty:  0.04688327
p_int:  0.816738273
p_ni:  0.183261727
Score:  0.215
Data Source:  BioPlex,STRINGDB
POF1B
Tbio
Novelty:  0.1232792
p_int:  0.762039279
p_ni:  0.23796072
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
94.4
2
2
0
1.1
80.3
2
2
0
1.1
73.4
childhood onset asthma
2
1
0
1.1
72.3
eosinophil percentage of leukocytes
1
1
1
68.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
94.4
0
1.1
80.3
0
1.1
73.4
childhood onset asthma
0
1.1
72.3
eosinophil percentage of leukocytes
1
68.8
Find similar targets by:
IDG Resources
Genetic Construct
GPR18-Tango
image for GPR18-Tango
Details:
  • Vector:  addgene66340
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR18-Tango
Order Genetic Construct from:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 18
VGNC:5065
738311
Macaque
G protein-coupled receptor 18
698714
Mouse
MGI:107859
110168
Rat
RGD:1304889
679957
Dog
G protein-coupled receptor 18
VGNC:41420
485531
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 18
Macaque
G protein-coupled receptor 18
Mouse
Rat
Dog
G protein-coupled receptor 18
Publication Statistics
PubMed Score 73.10
PubMed score by year
PubTator Score 21.58
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title