Tbio FKBP8 Peptidyl-prolyl cis-trans isomerase FKBP8

Protein Summary

Description

Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14318
• C8C9T5
• Q53GU3
• Q7Z349
• Q86YK6
• PPIase FKBP8

Gene Name

• FKBP8

Ensembl ID

• ENST00000222308
• ENSP00000222308
• ENSG00000105701
• ENST00000596558
• ENSP00000472302
• ENST00000597960
• ENSP00000471700
• ENST00000608443
• ENSP00000476767

Symbol

• FKBP38
• FKBP38
• FKBPr38

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
interacting protein	0.9
histone modification site profile	0.82
kinase perturbation	0.76
transcription factor binding site profile	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.61   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 381   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.61   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0