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Tbio
FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

Protein Summary
Description
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222308
  • ENSP00000222308
  • ENSG00000105701
  • ENST00000596558
  • ENSP00000472302
  • ENST00000597960
  • ENSP00000471700
  • ENST00000608443
  • ENSP00000476767

Symbol
  • FKBP38
  • FKBP38
  • FKBPr38
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
interacting protein
0.9
histone modification site profile
0.82
kinase perturbation
0.76
transcription factor binding site profile
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.98   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 381   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.98   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
potassium measurement
1
1
1
43.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
potassium measurement
1
43.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FK506 binding protein 8
VGNC:2405
455862
Macaque
FK506 binding protein 8
720232
Mouse
MGI:1341070
14232
Rat
RGD:1308670
290652
Dog
FK506 binding protein 8
VGNC:40894
484819
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FK506 binding protein 8
Macaque
FK506 binding protein 8
Mouse
Rat
Dog
FK506 binding protein 8
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14318-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (68)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Protein-Protein Interactions (115)
1 – 10 of 115
ANKMY2
Tdark
Novelty: 0.50777631
p_int: 0.967456234
p_ni: 0.032543766
Score: 0.516
Data Source: BioPlex,STRINGDB
BCL2
Tclin
Novelty: 0.00608635
Score: 0.935
Data Source: STRINGDB
RHOT1
Tbio
Family: Enzyme
Novelty: 0.01411527
Score: 0.928
Data Source: STRINGDB
VDAC1
Tbio
Novelty: 0.0011441
Score: 0.927
Data Source: STRINGDB
TOMM70
Tbio
Novelty: 0.00943973
Score: 0.925
Data Source: STRINGDB
TOMM20
Tbio
Novelty: 0.00275824
Score: 0.917
Data Source: STRINGDB
VDAC2
Tchem
Novelty: 0.00575936
Score: 0.912
Data Source: STRINGDB
VDAC3
Tbio
Novelty: 0.0095068
Score: 0.91
Data Source: STRINGDB
MUL1
Tbio
Family: Enzyme
Novelty: 0.00841786
Score: 0.909
Data Source: STRINGDB
IDE
Tchem
Family: Enzyme
Novelty: 0.00207793
Score: 0.904
Data Source: STRINGDB
Publication Statistics
PubMed Score  64.98

PubMed score by year
PubTator Score  37.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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