Protein Summary
Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000325888
- ENSP00000327145
- ENSG00000128591
- ENST00000346177
- ENSP00000344002
- ABPL
- FLN2
- ABPA
- ABPL
- FLN2
- MFM5
- MPD4
- RCM5
- CMH26
- ABP-280
- ABP280A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
protein domain | 0.97 | ||
hub protein | 0.88 | ||
PubMedID | 0.84 | ||
transcription factor | 0.76 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 229.11 (req: < 5)
Gene RIFs: 46 (req: <= 3)
Antibodies: 132 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 229.11 (req: >= 5)
Gene RIFs: 46 (req: > 3)
Antibodies: 132 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | filamin C | VGNC:14011 | 463711 | |||||
Macaque | filamin C | 700223 | ||||||
Mouse | MGI:95557 | 68794 | ||||||
Rat | RGD:1308807 | 362332 | ||||||
Dog | filamin C | VGNC:40902 | 482266 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | filamin C | |||||
Macaque | filamin C | |||||
Mouse | ||||||
Rat | ||||||
Dog | filamin C | |||||
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (192)
Reactome (3)
KEGG (4)
WikiPathways (185)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-extracellular matrix interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-extracellular matrix interactions | ||||
Gene Ontology Terms (15)
Functions (4)
Components (9)
Processes (2)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | AgBase | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (185)
1 – 10 of 185
LAD1
Novelty: 0.03059679
p_int: 0.99993859
p_ni: 0.00006141
Data Source: BioPlex
HSPB7
Novelty: 0.03344805
p_int: 0.999935381
p_ni: 0.000064619
Score: 0.728
Data Source: BioPlex,STRINGDB
NUDT5
Family: Enzyme
Novelty: 0.02550535
p_int: 0.99970651
p_ni: 0.00029349
Data Source: BioPlex
RAB8B
Family: Enzyme
Novelty: 0.06230082
p_int: 0.999702765
p_ni: 0.000297235
Score: 0.207
Data Source: BioPlex,STRINGDB
NUAK2
Family: Kinase
Novelty: 0.02463599
p_int: 0.99673498
p_ni: 0.00326502
Score: 0.218
Data Source: BioPlex,STRINGDB
FBLIM1
Novelty: 0.0332985
p_int: 0.99519338
p_ni: 0.00480662
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
GNG3
Novelty: 0.16941216
p_int: 0.99486241
p_ni: 0.00513759
Data Source: BioPlex
LRRC61
Novelty: 1.45343096
p_int: 0.989629878
p_ni: 0.010370122
Data Source: BioPlex
KCTD13
Novelty: 0.07000508
p_int: 0.96546384
p_ni: 0.03453616
Score: 0.759
Data Source: BioPlex,STRINGDB
NT5C
Family: Enzyme
Novelty: 0.00686933
p_int: 0.960066526
p_ni: 0.039933474
Score: 0.16
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 229.11
PubMed score by year
PubTator Score 405.74
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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