Tbio FLNC Filamin-C

Protein Summary

Description

Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14315
• B2ZZ88
• O95303
• Q07985
• Q9NS12
• Q9NYE5
• Q9UMR8
• Q9Y503
• FLN-C

Gene Name

• FLNC

Ensembl ID

• ENST00000325888
• ENSP00000327145
• ENSG00000128591
• ENST00000346177
• ENSP00000344002

Symbol

• ABPL
• FLN2
• ABPA
• ABPL
• FLN2
• MFM5
• MPD4
• RCM5
• CMH26
• ABP-280
• ABP280A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
protein domain	0.97
hub protein	0.88
PubMedID	0.84
transcription factor	0.76

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.11   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 132   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.11   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	filamin C	VGNC:14011	463711
Macaque	filamin C		700223
Mouse	filamin C, gamma	MGI:95557	68794
Rat	filamin C	RGD:1308807	362332
Dog	filamin C	VGNC:40902	482266

Species	Name	OMA	EggNOG	Inparanoid
Chimp	filamin C
Macaque	filamin C
Mouse	filamin C, gamma
Rat	filamin C
Dog	filamin C

Protein Structure (10 Structures, 8 AlphaFold Models)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14315-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (192)

Reactome (3)

KEGG (4)

WikiPathways (185)

Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell junction organization	88 targets	R-HSA-446728
Reactome	Cell-Cell communication	121 targets	R-HSA-1500931
Reactome	Cell-extracellular matrix interactions	16 targets	R-HSA-446353

Name	Explore in Pharos	Explore in Source
Cell junction organization	88 targets	R-HSA-446728
Cell-Cell communication	121 targets	R-HSA-1500931
Cell-extracellular matrix interactions	16 targets	R-HSA-446353

Gene Ontology Terms (15)

Functions (4)

Components (9)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
ankyrin binding	Inferred from Physical Interaction (IPI)	BHF-UCL
cytoskeletal protein binding	Inferred from Physical Interaction (IPI)	AgBase
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
actin filament binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (185)

Explore Interacting Targets

1 – 10 of 185

• See Interactions on String-DB

LAD1

Tbio

Novelty: 0.03059679

p_int: 0.99993859

p_ni: 0.00006141

Data Source: BioPlex

HSPB7

Tbio

Novelty: 0.03344805

p_int: 0.999935381

p_ni: 0.000064619

Score: 0.728

Data Source: BioPlex,STRINGDB

NUDT5

Tbio

Family: Enzyme

Novelty: 0.02550535

p_int: 0.99970651

p_ni: 0.00029349

Data Source: BioPlex

RAB8B

Tbio

Family: Enzyme

Novelty: 0.06230082

p_int: 0.999702765

p_ni: 0.000297235

Score: 0.207

Data Source: BioPlex,STRINGDB

NUAK2

Tchem

Family: Kinase

Novelty: 0.02463599

p_int: 0.99673498

p_ni: 0.00326502

Score: 0.218

Data Source: BioPlex,STRINGDB

FBLIM1

Tbio

Novelty: 0.0332985

p_int: 0.99519338

p_ni: 0.00480662

Score: 0.997

Data Source: BioPlex,Reactome,STRINGDB

GNG3

Tbio

Novelty: 0.16941216

p_int: 0.99486241

p_ni: 0.00513759

Data Source: BioPlex

LRRC61

Tdark

Novelty: 1.45343096

p_int: 0.989629878

p_ni: 0.010370122

Data Source: BioPlex

KCTD13

Tbio

Novelty: 0.07000508

p_int: 0.96546384

p_ni: 0.03453616

Score: 0.759

Data Source: BioPlex,STRINGDB

NT5C

Tbio

Family: Enzyme

Novelty: 0.00686933

p_int: 0.960066526

p_ni: 0.039933474

Score: 0.16

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  229.11

PubMed score by year

Reset Zoom

PubTator Score  405.74

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

3D-structure
Actin-binding
Alternative splicing
Cardiomyopathy
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
Membrane

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype
mortality/aging
muscle phenotype
respiratory system phenotype