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Tbio
FLNC
Filamin-C

Protein Summary
Description
Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325888
  • ENSP00000327145
  • ENSG00000128591
  • ENST00000346177
  • ENSP00000344002

Symbol
  • ABPL
  • FLN2
  • ABPA
  • ABPL
  • FLN2
  • MFM5
  • MPD4
  • RCM5
  • CMH26
  • ABP-280
  • ABP280A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein domain
0.97
hub protein
0.88
PubMedID
0.84
transcription factor
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.69   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.69   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (185)
LAD1
Tbio
Novelty:  0.03059679
p_int:  0.99993859
p_ni:  0.00006141
Data Source:  BioPlex
HSPB7
Tbio
Novelty:  0.03344805
p_int:  0.999935381
p_ni:  0.000064619
Score:  0.728
Data Source:  BioPlex,STRINGDB
NUDT5
Tbio
Family:  Enzyme
Novelty:  0.02550535
p_int:  0.99970651
p_ni:  0.00029349
Data Source:  BioPlex
RAB8B
Tbio
Family:  Enzyme
Novelty:  0.06230082
p_int:  0.999702765
p_ni:  0.000297235
Score:  0.207
Data Source:  BioPlex,STRINGDB
NUAK2
Tchem
Family:  Kinase
Novelty:  0.02463599
p_int:  0.99673498
p_ni:  0.00326502
Score:  0.218
Data Source:  BioPlex,STRINGDB
FBLIM1
Tbio
Novelty:  0.0332985
p_int:  0.99519338
p_ni:  0.00480662
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
GNG3
Tbio
Novelty:  0.16941216
p_int:  0.99486241
p_ni:  0.00513759
Data Source:  BioPlex
LRRC61
Tdark
Novelty:  1.45343096
p_int:  0.989629878
p_ni:  0.010370122
Data Source:  BioPlex
KCTD13
Tbio
Novelty:  0.07000508
p_int:  0.96546384
p_ni:  0.03453616
Score:  0.759
Data Source:  BioPlex,STRINGDB
NT5C
Tbio
Family:  Enzyme
Novelty:  0.00686933
p_int:  0.960066526
p_ni:  0.039933474
Score:  0.16
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 4 of 4
ROCK1
Tclin
Family:  Kinase
KEGG Distance:  4
Common Pathways:  3
ERBB2
Tclin
Family:  Kinase
KEGG Distance:  4
Common Pathways:  3
ROCK2
Tclin
Family:  Kinase
KEGG Distance:  4
Common Pathways:  3
IL1R1
Tclin
Family:  Other
KEGG Distance:  4
Common Pathways:  1
Pathways (192)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-extracellular matrix interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-extracellular matrix interactions
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
13
9
0
1.7
99.3
mathematical ability
4
2
4
89.8
self reported educational attainment
3
2
3
89.6
5
5
2
1.2
86.2
eosinophil count
2
2
2
83.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
99.3
mathematical ability
4
89.8
self reported educational attainment
3
89.6
2
1.2
86.2
eosinophil count
2
83.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
filamin C
VGNC:14011
463711
Macaque
filamin C
700223
Mouse
MGI:95557
68794
Rat
RGD:1308807
362332
Dog
filamin C
VGNC:40902
482266
Species
Name
OMA
EggNOG
Inparanoid
Chimp
filamin C
Macaque
filamin C
Mouse
Rat
Dog
filamin C
Publication Statistics
PubMed Score 246.69
PubMed score by year
PubTator Score 405.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title