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Tclin
PTK2B
Protein-tyrosine kinase 2-beta

Protein Summary
Description
Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346049
  • ENSP00000332816
  • ENSG00000120899
  • ENST00000397501
  • ENSP00000380638
  • ENST00000420218
  • ENSP00000391995
  • ENST00000517339
  • ENSP00000427931

Symbol
  • FAK2
  • PYK2
  • RAFTK
  • PKB
  • PTK
  • CAKB
  • FAK2
  • PYK2
  • CADTK
  • FADK2
  • RAFTK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
interacting protein
1
molecular function
1
protein domain
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 712.37   (req: < 5)
Gene RIFs: 161   (req: <= 3)
Antibodies: 936   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 712.37   (req: >= 5)
Gene RIFs: 161   (req: > 3)
Antibodies: 936   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 100
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 44
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1