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Tclin
PTK2B
Protein-tyrosine kinase 2-beta

Protein Summary
Description
Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346049
  • ENSP00000332816
  • ENSG00000120899
  • ENST00000397501
  • ENSP00000380638
  • ENST00000420218
  • ENSP00000391995
  • ENST00000517339
  • ENSP00000427931

Symbol
  • FAK2
  • PYK2
  • RAFTK
  • PKB
  • PTK
  • CAKB
  • FAK2
  • PYK2
  • CADTK
  • FADK2
  • RAFTK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
interacting protein
1
molecular function
1
protein domain
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 626.01   (req: < 5)
Gene RIFs: 161   (req: <= 3)
Antibodies: 936   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 626.01   (req: >= 5)
Gene RIFs: 161   (req: > 3)
Antibodies: 936   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 100
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 37
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
lorlatinib
chemical structure image
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1
0
1.1
89.3
family history of Alzheimer’s disease
2
1
0
3.9
88.9
1
1
0
1.9
72.9
eosinophil count
2
2
2
70.4
monocyte count
1
1
1
69.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
89.3
family history of Alzheimer’s disease
0
3.9
88.9
0
1.9
72.9
eosinophil count
2
70.4
monocyte count
1
69.1
Protein Data Bank (23)
1 – 5 of 23
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (58)
Cell-Cell communication (R-HSA-1500931)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell-Cell communication
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-2 family signaling
Reactome
Interleukin-2 signaling
Name
Explore in Pharos
Explore in Source
Cell-Cell communication
Cytokine Signaling in Immune system
Immune System
Interleukin-2 family signaling
Interleukin-2 signaling
Gene Ontology Terms (119)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
Alzheimers_University_of_Toronto
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (265)
1 – 10 of 265
PXN
Tbio
Novelty: 0.00082031
Score: 0.999
Data Source: STRINGDB
BCAR1
Tbio
Novelty: 0.00329214
Score: 0.992
Data Source: STRINGDB
LPXN
Tbio
Novelty: 0.00796678
Score: 0.987
Data Source: STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.985
Data Source: STRINGDB
TGFB1I1
Tbio
Novelty: 0.0120375
Score: 0.983
Data Source: STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.982
Data Source: STRINGDB
SHC1
Tchem
Novelty: 0.00083615
Score: 0.971
Data Source: STRINGDB
CRK
Tbio
Novelty: 0.00238512
Score: 0.97
Data Source: STRINGDB
ITGB3
Tclin
Novelty: 0.00067255
Score: 0.965
Data Source: Reactome,STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.964
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  626.01

PubMed score by year
PubTator Score  1002.82

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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