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Tclin
PTK2B
Protein-tyrosine kinase 2-beta

Protein Summary
Description
Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346049
  • ENSP00000332816
  • ENSG00000120899
  • ENST00000397501
  • ENSP00000380638
  • ENST00000420218
  • ENSP00000391995
  • ENST00000517339
  • ENSP00000427931

Symbol
  • FAK2
  • PYK2
  • RAFTK
  • PKB
  • PTK
  • CAKB
  • FAK2
  • PYK2
  • CADTK
  • FADK2
  • RAFTK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
interacting protein
1
molecular function
1
protein domain
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 637.1   (req: < 5)
Gene RIFs: 161   (req: <= 3)
Antibodies: 936   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 637.1   (req: >= 5)
Gene RIFs: 161   (req: > 3)
Antibodies: 936   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 100
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 42
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (265)
PXN
Tbio
Novelty:  0.00082031
Score:  0.999
Data Source:  STRINGDB
BCAR1
Tbio
Novelty:  0.00329214
Score:  0.992
Data Source:  STRINGDB
LPXN
Tbio
Novelty:  0.00796678
Score:  0.987
Data Source:  STRINGDB
GRB2
Tchem
Novelty:  0.00091605
Score:  0.985
Data Source:  STRINGDB
TGFB1I1
Tbio
Novelty:  0.0120375
Score:  0.983
Data Source:  STRINGDB
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
Score:  0.982
Data Source:  STRINGDB
SHC1
Tchem
Novelty:  0.00083615
Score:  0.971
Data Source:  STRINGDB
CRK
Tchem
Novelty:  0.00238512
Score:  0.97
Data Source:  STRINGDB
ITGB3
Tclin
Novelty:  0.00067255
Score:  0.965
Data Source:  Reactome,STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.964
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (58)
Cell-Cell communication (R-HSA-1500931)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell-Cell communication
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-2 family signaling
Reactome
Interleukin-2 signaling
Name
Explore in Pharos
Explore in Source
Cell-Cell communication
Cytokine Signaling in Immune system
Immune System
Interleukin-2 family signaling
Interleukin-2 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (119)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
Alzheimers_University_of_Toronto
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
82.6
family history of Alzheimer’s disease
2
2
0
5.9
77.4
4
2
0
1.1
77.4
smoking initiation
2
2
2
77
eosinophil count
2
2
2
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
82.6
family history of Alzheimer’s disease
0
5.9
77.4
0
1.1
77.4
smoking initiation
2
77
eosinophil count
2
70.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine kinase 2 beta
VGNC:811
464073
Macaque
protein tyrosine kinase 2 beta
712787
Mouse
MGI:104908
19229
Rat
RGD:628758
50646
Dog
protein tyrosine kinase 2 beta
VGNC:45159
486102
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine kinase 2 beta
Macaque
protein tyrosine kinase 2 beta
Mouse
Rat
Dog
protein tyrosine kinase 2 beta
Publication Statistics
PubMed Score 637.10
PubMed score by year
PubTator Score 1002.82
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title