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Tbio
TRIM25
E3 ubiquitin/ISG15 ligase TRIM25

Protein Summary
Description
Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this prot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316881
  • ENSP00000323889
  • ENSG00000121060
  • ENST00000537230
  • ENSP00000445961

Symbol
  • EFP
  • RNF147
  • ZNF147
  • EFP
  • Z147
  • RNF147
  • ZNF147
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.97
transcription factor binding site profile
0.96
small molecule perturbation
0.93
PubMedID
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.86   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 473   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.86   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 473   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (117)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
DNA Damage Bypass
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
DNA Damage Bypass
DNA Repair
Gene Ontology Terms (29)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Mutant Phenotype (IMP)
ParkinsonsUK-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (307)
1 – 10 of 307
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.99956361
p_ni: 0.000436388
p_wrong: 3e-9
Data Source: BioPlex
TCEAL1
Tbio
Novelty: 0.02210924
p_int: 0.996575946
p_ni: 0.003421203
p_wrong: 0.000002851
Score: 0.173
Data Source: BioPlex,STRINGDB
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.996422897
p_ni: 0.001736906
p_wrong: 0.001840197
Score: 0.214
Data Source: BioPlex,STRINGDB
FAM24B
Tdark
Novelty: 1.04675689
p_int: 0.996234295
p_ni: 0.003693245
p_wrong: 0.000072461
Data Source: BioPlex
G3BP2
Tbio
Family: Enzyme
Novelty: 0.04786241
p_int: 0.926957766
p_ni: 0.07299499
p_wrong: 0.000047244
Score: 0.475
Data Source: BioPlex,STRINGDB
DDX58
Tbio
Family: Enzyme
Novelty: 0.00080099
Score: 0.995
Data Source: Reactome,STRINGDB
MAVS
Tbio
Novelty: 0.00241215
Score: 0.993
Data Source: Reactome,STRINGDB
UBE2N
Tbio
Novelty: 0.00620946
Score: 0.991
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.988
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.982
Data Source: STRINGDB
Publication Statistics
PubMed Score  213.86

PubMed score by year
PubTator Score  73.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer