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Tbio
RCN2
Reticulocalbin-2

Protein Summary
Description
Not known. Binds calcium. The protein encoded by this gene is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. This gene maps to the same region as type 4 Bardet-Biedl syndrome, suggesting a possible causative role for this gene in the disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320963
  • ENSP00000319739
  • ENSG00000117906
  • ENST00000394885
  • ENSP00000378349

Symbol
  • ERC55
  • E6BP
  • ERC55
  • ERC-55
  • TCBP49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
virus
0.98
virus perturbation
0.94
viral protein
0.93
disease perturbation
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.81   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.81   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
0.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
0.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
reticulocalbin 2
VGNC:2470
467833
Macaque
reticulocalbin 2
708127
Mouse
MGI:1349765
26611
Rat
RGD:3548
29218
Dog
reticulocalbin 2
VGNC:54349
487666
Species
Name
OMA
EggNOG
Inparanoid
Chimp
reticulocalbin 2
Macaque
reticulocalbin 2
Mouse
Rat
Dog
reticulocalbin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14257-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (57)
1 – 10 of 57
PIGX
Tdark
Novelty: 1.9278829
Score: 0.831
Data Source: STRINGDB
NPTX1
Tbio
Novelty: 0.02872516
Score: 0.817
Data Source: STRINGDB
SFXN1
Tbio
Novelty: 0.09832047
Score: 0.812
Data Source: STRINGDB
NPTXR
Tbio
Novelty: 0.00727951
Score: 0.804
Data Source: STRINGDB
KDELR1
Tbio
Novelty: 0.0036468
Score: 0.768
Data Source: STRINGDB
NPTX2
Tbio
Novelty: 0.00686292
Score: 0.71
Data Source: STRINGDB
CHP1
Tbio
Novelty: 0.01299969
Score: 0.69
Data Source: STRINGDB
UBE3A
Tbio
Family: Enzyme
Novelty: 0.00149368
Score: 0.68
Data Source: STRINGDB
SIPA1L1
Tdark
Novelty: 0.13134052
Score: 0.677
Data Source: STRINGDB
TMBIM4
Tbio
Novelty: 0.00736177
Score: 0.672
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.81

PubMed score by year
PubTator Score  18.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer