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Tbio
FLOT2
Flotillin-2

Protein Summary
Description
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394908
  • ENSP00000378368
  • ENSG00000132589

Symbol
  • ESA1
  • M17S1
  • ESA
  • ECS1
  • ESA1
  • ECS-1
  • M17S1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
transcription factor perturbation
0.91
kinase perturbation
0.88
cellular component
0.79
interacting protein
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.27   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.27   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
5
5
5
98.9
red blood cell distribution width
4
4
4
98.8
reticulocyte count
4
3
4
94
reticulocyte measurement
2
2
2
89.1
hemoglobin measurement
2
2
2
84.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
5
98.9
red blood cell distribution width
4
98.8
reticulocyte count
4
94
reticulocyte measurement
2
89.1
hemoglobin measurement
2
84.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
flotillin 2
VGNC:9433
454537
Macaque
flotillin 2
716527
Mouse
MGI:103309
14252
Rat
RGD:70993
83764
Horse
flotillin 2
VGNC:18064
100072090
Species
Name
OMA
EggNOG
Inparanoid
Chimp
flotillin 2
Macaque
flotillin 2
Mouse
Rat
Horse
flotillin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14254-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Reactome
Synaptic adhesion-like molecules
Name
Explore in Pharos
Explore in Source
Neuronal System
Protein-protein interactions at synapses
Synaptic adhesion-like molecules
Protein-Protein Interactions (72)
1 – 10 of 72
TMEM79
Tbio
Novelty:  0.0624393
p_int:  0.999999991
p_ni:  9e-9
Score:  0.359
Data Source:  BioPlex,STRINGDB
MPC2
Tbio
Novelty:  0.02948696
p_int:  0.975256648
p_ni:  0.02474268
p_wrong:  6.71e-7
Score:  0.513
Data Source:  BioPlex,STRINGDB
GORASP2
Tbio
Novelty:  0.02121907
p_int:  0.899605181
p_ni:  0.100394819
Score:  0.221
Data Source:  BioPlex,STRINGDB
TBC1D15
Tbio
Novelty:  0.11296513
p_int:  0.883494323
p_ni:  0.116505674
p_wrong:  3e-9
Score:  0.252
Data Source:  BioPlex,STRINGDB
MPZL3
Tbio
Novelty:  0.25092947
p_int:  0.857821909
p_ni:  6.9e-8
p_wrong:  0.142178022
Score:  0.689
Data Source:  BioPlex,STRINGDB
CAV1
Tbio
Novelty:  0.00035244
Score:  0.971
Data Source:  STRINGDB
FLOT1
Tbio
Novelty:  0.00504569
Score:  0.968
Data Source:  STRINGDB
CDH1
Tbio
Novelty:  0.00010629
Score:  0.92
Data Source:  STRINGDB
LRFN3
Tdark
Novelty:  0.30018245
Score:  0.905
Data Source:  Reactome,STRINGDB
SLC6A3
Tclin
Family:  Transporter
Novelty:  0.00017601
Score:  0.903
Data Source:  STRINGDB
Publication Statistics
PubMed Score  141.27

PubMed score by year
PubTator Score  95.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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