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Tbio
ENDOG
Endonuclease G, mitochondrial

Protein Summary
Description
Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity). The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372642
  • ENSP00000361725
  • ENSG00000167136
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
kinase perturbation
0.71
transcription factor binding site profile
0.69
histone modification site profile
0.65
chemical
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.46   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 438   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.46   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 438   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (26)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (121)
1 – 10 of 121
DNAJA1
Tchem
Novelty: 0.01437758
p_int: 0.999979534
p_ni: 0.000020466
Score: 0.267
Data Source: BioPlex,STRINGDB
CST5
Tbio
Novelty: 0.05255793
p_int: 0.999954876
p_ni: 0.000040628
p_wrong: 0.000004495
Data Source: BioPlex
NFYC
Tbio
Family: TF
Novelty: 0.01108426
p_int: 0.999247385
p_ni: 0.000752615
Data Source: BioPlex
EVL
Tbio
Novelty: 0.00507124
p_int: 0.9987966
p_ni: 0.001203372
p_wrong: 2.8e-8
Data Source: BioPlex
ITLN1
Tbio
Novelty: 0.00284601
p_int: 0.998666573
p_ni: 0.001333427
Score: 0.798
Data Source: BioPlex,STRINGDB
KCTD12
Tbio
Novelty: 0.03918969
p_int: 0.997653194
p_ni: 0.00233799
p_wrong: 0.000008816
Data Source: BioPlex
GRK6
Tchem
Family: Kinase
Novelty: 0.0342143
p_int: 0.994887467
p_ni: 0.005112533
Score: 0.204
Data Source: BioPlex,STRINGDB
BAG4
Tbio
Novelty: 0.03955483
p_int: 0.978235481
p_ni: 0.021764517
p_wrong: 2e-9
Score: 0.153
Data Source: BioPlex,STRINGDB
ITLN2
Tbio
Novelty: 0.15044776
p_int: 0.975229638
p_ni: 0.024770356
p_wrong: 6e-9
Score: 0.874
Data Source: BioPlex,STRINGDB
PRKACG
Tbio
Family: Kinase
Novelty: 0.20113337
p_int: 0.953715422
p_ni: 0.046188477
p_wrong: 0.0000961
Score: 0.262
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  186.46

PubMed score by year
PubTator Score  134.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer