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Tbio
CTTN
Src substrate cortactin

Protein Summary
Description
Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301843
  • ENSP00000301843
  • ENSG00000085733
  • ENST00000346329
  • ENSP00000317189
  • ENST00000376561
  • ENSP00000365745

Symbol
  • EMS1
  • EMS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase
1
transcription factor perturbation
1
hub protein
0.99
ligand (protein) perturbation
0.99


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 589.19   (req: < 5)
Gene RIFs: 171   (req: <= 3)
Antibodies: 893   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 589.19   (req: >= 5)
Gene RIFs: 171   (req: > 3)
Antibodies: 893   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cortactin
708291
Mouse
MGI:99695
13043
Rat
RGD:619839
60465
Dog
cortactin
VGNC:39718
610283
Horse
cortactin
VGNC:16958
100147634
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cortactin
Mouse
Rat
Dog
cortactin
Horse
cortactin
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14247-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (61)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases activate PAKs
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Membrane Trafficking
RHO GTPase Effectors
RHO GTPases activate PAKs
Signal Transduction
Gene Ontology Terms (34)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (367)
1 – 10 of 367
ANKRD54
Tbio
Novelty: 0.03101679
p_int: 0.99999979
p_ni: 2.09e-7
Score: 0.224
Data Source: BioPlex,STRINGDB
MAN2C1
Tbio
Family: Enzyme
Novelty: 0.01159051
p_int: 0.999989235
p_ni: 0.000010765
Data Source: BioPlex
RPS6KA1
Tchem
Family: Kinase
Novelty: 0.00178073
p_int: 0.999936605
p_ni: 0.000063395
Score: 0.16
Data Source: BioPlex,STRINGDB
SH2D4A
Tbio
Novelty: 0.12343277
p_int: 0.998265538
p_ni: 0.001730969
p_wrong: 0.000003493
Data Source: BioPlex
HDAC6
Tclin
Family: Epigenetic
Novelty: 0.00122232
p_int: 0.997645638
p_ni: 0.002246804
p_wrong: 0.000107558
Score: 0.817
Data Source: BioPlex,STRINGDB
FECH
Tbio
Family: Enzyme
Novelty: 0.00282289
p_int: 0.976432649
p_ni: 0.023567351
Data Source: BioPlex
FKBP10
Tbio
Family: Enzyme
Novelty: 0.01512539
p_int: 0.872540465
p_ni: 0.127459535
Data Source: BioPlex
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.995
Data Source: STRINGDB
WASL
Tbio
Novelty: 0.0029314
Score: 0.994
Data Source: STRINGDB
HIP1R
Tbio
Novelty: 0.02502713
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  589.19

PubMed score by year
PubTator Score  429.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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