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Tbio
ADGRE1
Adhesion G protein-coupled receptor E1

Protein Summary
Description
Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development. This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250572
  • ENSP00000250572
  • ENSG00000174837
  • ENST00000312053
  • ENSP00000311545
  • ENST00000381404
  • ENSP00000370811
  • ENST00000381407
  • ENSP00000370814
  • ENST00000450315
  • ENSP00000405974

Symbol
  • EMR1
  • TM7LN3
  • EMR1
  • TM7LN3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
gene perturbation
0.97
transcription factor perturbation
0.88
virus perturbation
0.76
tissue sample
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.62   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 644   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.62   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 644   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0