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Tbio
ADGRE1
Adhesion G protein-coupled receptor E1

Protein Summary
Description
Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development. This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250572
  • ENSP00000250572
  • ENSG00000174837
  • ENST00000312053
  • ENSP00000311545
  • ENST00000381404
  • ENSP00000370811
  • ENST00000381407
  • ENSP00000370814
  • ENST00000450315
  • ENSP00000405974

Symbol
  • EMR1
  • TM7LN3
  • EMR1
  • TM7LN3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
gene perturbation
0.97
transcription factor perturbation
0.88
virus perturbation
0.76
tissue sample
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.82   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 644   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.82   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 644   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor E1
VGNC:6605
741193
Macaque
adhesion G protein-coupled receptor E1
100424335
Mouse
MGI:106912
13733
Rat
RGD:1359214
316137
Dog
adhesion G protein-coupled receptor E1
VGNC:37636
485015
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor E1
Macaque
adhesion G protein-coupled receptor E1
Mouse
Rat
Dog
adhesion G protein-coupled receptor E1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14246-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (92)
1 – 10 of 92
CSF1R
Tclin
Family: Kinase
Novelty: 0.00064143
Score: 0.759
Data Source: STRINGDB
ITGAM
Tbio
Novelty: 0.00017521
Score: 0.754
Data Source: STRINGDB
ITGAX
Tbio
Novelty: 0.00040471
Score: 0.734
Data Source: STRINGDB
MRC1
Tbio
Novelty: 0.00104675
Score: 0.726
Data Source: STRINGDB
PTPRC
Tchem
Family: Enzyme
Novelty: 0.00012027
Score: 0.718
Data Source: STRINGDB
IL6
Tclin
Novelty: 0.00001819
Score: 0.692
Data Source: STRINGDB
TNF
Tclin
Novelty: 0.00001457
Score: 0.688
Data Source: STRINGDB
IL10
Tbio
Novelty: 0.00004352
Score: 0.659
Data Source: STRINGDB
CD86
Tclin
Novelty: 0.00029965
Score: 0.659
Data Source: STRINGDB
CD19
Tclin
Novelty: 0.0001816
Score: 0.649
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.82

PubMed score by year
PubTator Score  20.06

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer