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Tbio
SELPLG
P-selectin glycoprotein ligand 1

Protein Summary
Description
A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. (Microbial infection) Acts as a receptor for enterovirus 71. This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228463
  • ENSP00000228463
  • ENSG00000110876
  • ENST00000550948
  • ENSP00000447752

Symbol
  • CLA
  • CD162
  • PSGL1
  • PSGL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
biological term
0.92
transcription factor perturbation
0.8
gene perturbation
0.7
tissue sample
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 637.59   (req: < 5)
Gene RIFs: 137   (req: <= 3)
Antibodies: 957   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 637.59   (req: >= 5)
Gene RIFs: 137   (req: > 3)
Antibodies: 957   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (114)
SELP
Tclin
Novelty:  0.00019779
Score:  0.999
Data Source:  Reactome,STRINGDB
SELL
Tchem
Novelty:  0.00030025
Score:  0.996
Data Source:  Reactome,STRINGDB
SELE
Tchem
Novelty:  0.00029494
Score:  0.994
Data Source:  Reactome,STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.966
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.962
Data Source:  STRINGDB
ESAM
Tbio
Novelty:  0.00462452
Score:  0.923
Data Source:  Reactome,STRINGDB
SNX20
Tdark
Novelty:  0.28934317
Score:  0.856
Data Source:  STRINGDB
FUT7
Tchem
Family:  Enzyme
Novelty:  0.01257357
Score:  0.85
Data Source:  STRINGDB
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Score:  0.78
Data Source:  STRINGDB
GLG1
Tbio
Novelty:  0.01332149
Score:  0.699
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
4
4
64.2
reticulocyte measurement
2
2
2
49.1
heel bone mineral density
2
1
2
44.2
serum non-albumin protein measurement
1
1
1
38.8
cognitive function measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
64.2
reticulocyte measurement
2
49.1
heel bone mineral density
2
44.2
serum non-albumin protein measurement
1
38.8
cognitive function measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
selectin P ligand
VGNC:13443
452211
Macaque
selectin P ligand
706046
Mouse
MGI:106689
20345
Rat
RGD:1307971
363930
Dog
selectin P ligand
VGNC:45986
611673
Species
Name
OMA
EggNOG
Inparanoid
Chimp
selectin P ligand
Macaque
selectin P ligand
Mouse
Rat
Dog
selectin P ligand
Publication Statistics
PubMed Score 637.59
PubMed score by year
PubTator Score 775.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title